Comparison study the effect of nimodipine, magnesium sulfate and progesterone in the treatment of severe head injury with conventional therapy on reducing mortality rate

The aim of the study: Comparison study the effect of nimodipine, magnesium sulfate and progesterone in the treatment of severe head injury with conventional therapy on reducing mortality rate study design: Randomized, Non-blinded, Non-placebo-controlled, Single-center‚ parallel Study population: Inclusion criteria: All patients with head injury and with Glascow Coma Scale lower than 8 who will refers to Emergency ward of Besat Hospital in the 1392 year. Exclusion criteria: Pregnant woman Any type of brain surgery instability from surgical aspect Using estrogen and progesterone in the last 30 days Brain death Systolic blood pressure below 90 Patients with kidney problems Sample volume: One hundred and twenty four patients in the two randomized group by using blocks. Interventions and the timing: Control group: They will be treat as routine: 1) Anti-seizure drugs, 2) Serum therapy, 3)Dexamethasone if needed 4), Doing necessary action according to the clinical situation. Cases group: In addition to routine treatments: These patients will receive progesterone based on a mg per kg(s) initially and then the same amount every 12 hours for 5 days, nimodipine 60 milli grams every 4 hours for 21 days, and 5 grams of magnesium sulfate initially and than 2 and a half grams daily for 5 days. Primary outcome: Reduction in mortality in cases group compared to the control group.

Hamedan University of Medical Sciences-vice chancellor for research