This study is a blind clinical trial will be done on 72 patients (cannot able to communicate and report pain) who admitted to intensive care unit of Tehran University of Medical Sciences Hospitals. If the patients have all inclusion criteria, after obtaining consent from their families, will be enrolled in the study. The patients randomly allocated into two groups, intervention and control. Ten minutes before the intervention, the pain will be measured and recorded by using CPOT, vital signs (systolic pressure, diastolic pressure, mean arterial pressure and pulse rate) and arterial blood oxygen saturation with checking the monitoring system, in the groups. The intervention group will listen to selected music using MP3 player with headphones for 30 minutes for three days. Thirty minutes after the intervention, the vital signs and pain will be assessed. Moreover, during the intervention, arterial blood oxygen saturation and vital signs will be assessed every 10 minutes in both of groups. In the control group will not be done any intervention during the 30 minutes and they only must be rest during this periods. The primary outcomes of the study will be vital signs, oxygen saturation and behavioral pain score.