The aim of study is to explore the probable positive effects of vaccinium myrtillus and Cinnamomum zeylanicum on the petrochemical workers through measuring blood oxidative stress markers such as total antioxidant capacity (TAC), total thiol molecules (TTM), lipid peroxidation (LPO), myeloperoxidase (MPO), and DNA damage as the marker of genotoxicity. Male painter with age range 25-45 and the least 5 work history will be inclued the study. Individuals with chronic disease, alcohol consumption, antioxidant consumption, and/or under drug treatment, or exposure to toxic materials, radiation therapy, or substance abuse will be exclud from the study. The study will be perform on 50 male workers who work in petrochemical company. The included subjectswill be administer vaccinium myrtillus and Cinnamon mixture infusion (3 and 0.5 g/100 mL) twice a day for 30 days at 7:00 AM and 2:00 PM every day. .To survey effect of infusion on oxidative stress, befor and after using mixture infusion blood sample will be collect.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT2014010810003N6
Registration date:2014-09-07, 1393/06/16
Registration timing:registered_while_recruiting
Last update:
Update count:0
Registration date
2014-09-07, 1393/06/16
Registrant information
Name
Ali akbar Malekirad
Name of organization / entity
Payame Noor University
Country
Iran (Islamic Republic of)
Phone
+98 86 2422 6073
Email address
malekirad@tabrizu.ac.ir
Recruitment status
Recruitment complete
Funding source
Islamic Uninersity of Damghan Branch
Expected recruitment start date
2014-09-06, 1393/06/15
Expected recruitment end date
2014-10-07, 1393/07/15
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
the effect of antioxidative capacity of cinnamon tea and Vaccinium myrtillus on oxidative stress in petrochemical worker
Public title
the effect of Vaccinium myrtillus and cinnamon on oxidative stress in petrochemical workers
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion Criteria:age range 25-45;male;the least 5 work history;petrochemical workers Exclusion Criteria: Individuals with chronic disease; alcohol consumption; antioxidant consumption; and/or under drug treatment; or exposure to toxic materials; radiation therapy; or substance abuse
Age
From 25 years old to 45 years old
Gender
Male
Phase
2-3
Groups that have been masked
No information
Sample size
Target sample size:
50
Randomization (investigator's opinion)
N/A
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Single
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Pharmaceutical Sciences Research Center, Tehran University of Medical Science
Street address
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Science, 16 Azar Street,Tehran 1417614411, Iran
City
Tehran
Postal code
1417614411
Approval date
2012-07-15, 1391/04/25
Ethics committee reference number
91-01-21:1-4
Health conditions studied
1
Description of health condition studied
Occupational exposure
ICD-10 code
Z57.5
ICD-10 code description
Occupational exposure to toxic agents in other industries
Primary outcomes
1
Description
total thiol groups
Timepoint
before and 30 day after intervention
Method of measurement
Hu method
2
Description
total antioxidant capacity of serum
Timepoint
before and 30 day after intervention
Method of measurement
Ferric Reducing Ability of Plasma method
3
Description
lipid peroxidation
Timepoint
before and 30 day after intervention
Method of measurement
thiobarbitturic acid method
4
Description
Myleoperoxidase activity
Timepoint
before and 30 day after intervention
Method of measurement
Elisa Method
5
Description
deoxyribonucleic acid Damage
Timepoint
before and 30 day after intervention
Method of measurement
Elisa method
Secondary outcomes
empty
Intervention groups
1
Description
The petrochemical workers will be administer vaccinium myrtillus and Cinnamon mixture decoction (3 and 0.5 g/100 mL) twice a day for 30 days at 7:00 AM and 2:00 PM every day.
Category
Prevention
Recruitment centers
1
Recruitment center
Name of recruitment center
Bandar Imam Petrochemical Complex
Full name of responsible person
Ali Akbar Malekirad
Street address
Bandar Imam Petrochemical Complex- Mahshahr- Iran
City
mahshahr
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Islamic Azad University of Damghan Branch
Full name of responsible person
Gholamhassan Vaezi
Street address
Islamic Azad University of Damghan Branch, Damghan, Iran
City
damghan
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Islamic Azad University of Damghan Branch
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Payame Noor University
Full name of responsible person
Aliَ Akbar Malekirad
Position
PhD.assistant prof.
Other areas of specialty/work
Street address
Amanipour Alley, Khoram street, Arak
City
Arak
Postal code
Phone
+98 86 1223 5541
Fax
Email
ak_malekirad@yahoo.com
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Payame Noor University
Full name of responsible person
Ali Akbar Malekirad
Position
Assistant prof. of Physiology
Other areas of specialty/work
Street address
Amanipour Alley, khoram street, Arak, Iran
City
Arak
Postal code
Phone
+98 86 1223 5541
Fax
Email
ak_malekirad@yahoo.com
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Payame Noor University
Full name of responsible person
Ali Akbar Malekirad
Position
PhD.assistant prof.
Other areas of specialty/work
Street address
Amanipour Alley, khoram street, Arak, Iran
City
Arak
Postal code
Phone
+98 86 1223 5541
Fax
Email
ak_malekirad@yahoo.com
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)