Therapeutic effect of heated, humidified, high-flow nasal cannula (HHHFNC) and Nasal intermittent mandatory ventilation (NIMV) as initial therapy of respiratory distress syndrome (RDS) in very Low Birth Weight (VLBW) Infants

Premature babies (especially VLBW) respiratory distress syndrome (RDS) may require respiratory support .Now is general agreement that the use of mechanical ventilation due to high to minimize side effects. For this reason; various methods of non-invasive ventilation (NRS) to reduce the use of mechanical ventilation is evolving and developing. The main advantage of this novel therapeutic approaches to reduce the rate of neonatal endotracheal tube intubation is. Infants were excluded if there was any of the following cases :Major congenital anomalies ;asphyxia and congenital cyanotic heart disease .In this study very low brith weight (BW<1500gr) with respiratory distress were considered eligible .Thirty-five infants were randomly assigned early NIMV and thirty-five comparable infants to early HHHFNC .Surfactant were given; when Fio2 requirement was of more than 30% .Shown that the application of continuous positive airway pressure to the airway through the nose (NCPAP) is one of the treatment options RDS in premature newborns that as an effective method to reduce the use of mechanical ventilation in a fairly large number of newborns preterm RDS is. Another method of treatment NRS nasal intermittent mechanical ventilation (NIMV) that the use of NIMV and HHHFNC post extubation and apea of prematurity are more effective than NCPAP. NIMV in the treatment of premature infants with RDS used. But do NIMV use as an initial treatment for RDS is controversial. In this way; despite the use of endotracheal intubation ventilation device can not be used and from nasal pronge.

Isfahan University of Medical Sciences