The purpose of this study was to evaluate the antioxidant effects of melatonin, melatonin and vitamin C alone and synergistic effects on periodontal clinical parameters. The study is a randomized, double-blind, placebo-controlled, single-center, phase one trial takes place. In this study, 69 patients older than 20 years will be enrolled with the following criteria: 1. Patients with moderate periodontitis, teeth excluding third molars 2. Patient must have a function 3. Lack of Systemic 4 - Full mouth score plaque above the 25%, 5 non-use of antibiotics in the previous quarter and exclusion criteria of the study are as follows: 1. pregnancy and breastfeeding (2) systemic disease; (3) the use of any medication placed in the hands of patients and classified the patients in the study group for the Blind before entering the study will be: 1 Protocol 1 (treatment phase): first, for each patient after charting, oral hygiene instruction is given and in charting index PD, BOP, CAL, plaque index, measured by the periodontist is unaware of the study. Pocket depth and attachment level measurements are performed in six areas of each tooth.Measuring the adhesion of the stent edges of preparation done before,then l patients treated with scaling and root Brvsazh the smooth surface in two sessions a week are at a distance.And for this purpose hand tools, devices and will be used Rabrkp and pumice paste and placebo in the form of a supplement to other patients are prepared.
2. Protocol 2 (Phase One treatment with melatonin administration): the implementation of the protocols 1, 2 mg melatonin supplement prescription pill, a pill every night for 30 days 3. Protocol 3 (Phase One treatment with melatonin administration and vitamin C), the performance of all acts of protocol 1, prescribe supplements of melatonin 2mg per night a 30-day prescription pill vitamin for women and 60 mg for men and 75 mg three times per day for 30 day clinical parameters before treatment and after 3 and 6 months post-treatment evaluation include: the primary outcome variable clinical attachment level (CAL) and secondary outcome variables bleeding during probing (BOP), probing depth (PD), plaque index. CAL, BOP and PD are measured by periodontal probe and plaque index is measured by the detector tablets