Purpose of present study was to survey the effect of resistance training on serum levels of interleukin-18 and high-sensitivity C-reactive protein in obese men. In a randomized design, eighteen obese men (body mass index more than 30 kilogram/meter squared,18-38 year), without experience of regular physical activity in one year before beginning of the study, history of cardiovascular diseases, diabetes, and thyroid diseases, drug consumption, being under any diet or medication, addiction to any narcotic substances, smoking, alcoholism, and caffeine were randomly placed at one of two groups: training and control. After 12-hour fasting, height, weight, body mass index, body fat percent, serum levels of interleukin-18 and high-sensitivity C-reactive protein were assessed before and after training. Resistance training protocol consisted of twelve weeks weight training (3 sessions per week, 10 stations, 3 sets 8-12 repetitions in each station, intensity 60-80% of one repetition maximum, rest between sets 1 min and between stations 2 min, duration of main training 60 min per each session).