The purpose of this study was to compare the prophylactic administration of cefazolin , ampicillin and azithromycin in the prevention of postpartum infections after cesarean. A total of 375 patients with non-elective cesarean candidates are placed randomly in three groups of 125 individuals. Inclusion criteria include non-elective caesarean section women candidates, gestational age 28 weeks or more. Exclusion criteria are hypersensitivity to cefazolin or ampicillin, or azithromycin; unwillingness patient; received systemic antibiotics within 2 weeks, prior cesarean delivery fever, PROM more than 18 hours, chorioamnionitis; receiving immunosuppressive drugs, the risk of diseases such as diabetes and immune deficiency: liver disease, kidney disease and heart failure or pulmonary edema active, have multiple pregnancies, preeclampsia, urinary tract infection or pneumonia, duration greater than one hour during subcutaneous drains. First group receive 2 g of cefazolin in 30 to 60 minutes before cutting. Second group receive regimen of 2 g of cefazolin in 30 to 60 minutes before cutting + 500 mg intravenous azithromycin and third group receive regimen of ampicillin 2 g in 30 to 60 minutes before cutting + 500 mg intravenous azithromycin. Determine the incidence of puerperal infection after cesarean section in all 3 groups at discharge, 2-week and 6-week and hospitalization period is recorded.