Comparison of the effect of Conventional yogurt with Probiotic yogurt on the level of salivary Streptococci Mutans of dental students of Islamic Azad University
Introduction : The yogurt has been considered as a healthy diet among the other snacks. Nowadays the production of probiotic yogurt is been increasing. In recent years several studys have pointed the potential ability of these products to decrease the level of oral cavity Streptococci Mutans. The aim of this study is to compare the effect of homemade Probiotic yogurt with conventional yogurt on the level of salivary Streptococci Mutans of dental students of Islamic Azad University in 1390.
Materials and Methods : Thirty dental students participate In this cross-over double-blinded randomized clinical trial study. The participant have been asked not to receive any antibiotic therapy 2-weeks before and during the study , also not to be exposed to any fluoride -contained or antibacterial mouthwashes , not to use any yogurt or probiotic products a week before and during the study , not to use any gums or Xylitol-contained products during the study .Each participantshave been asked to eat 200 cc amount of probiotic yogurt 10 minutes after dinner meal and not to brush their teeth for an hour after that. The level of of salivary Streptococci Mutans of participants has been measured at the beginning of study , after the each three intervention period ( the use of probiotic yogurt , conventional yogurt and use of none of them) and wash-out period. (intervention period lasts 3-weeks and wash-out period lasts 2-weeks apart). Mitis Salvarius Agar medium has been used to measure the load of bacterial culture. Each participants has been in 3 study group in a self-controlled manner.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT2012090210715N1
Registration date:2012-09-25, 1391/07/04
Registration timing:retrospective
Last update:
Update count:0
Registration date
2012-09-25, 1391/07/04
Registrant information
Name
Nesa Jamei
Name of organization / entity
Dental Faculty of Islamic Azad University of Tehran
Country
Iran (Islamic Republic of)
Phone
+98 61 1337 3843
Email address
nesa_jamei97@yahoo.com
Recruitment status
Recruitment complete
Funding source
Investigator
Expected recruitment start date
2011-10-02, 1390/07/10
Expected recruitment end date
2011-10-17, 1390/07/25
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Comparison of the effect of Conventional yogurt with Probiotic yogurt on the level of salivary Streptococci Mutans of dental students of Islamic Azad University
Public title
Comparison of the effect of Conventional yogurt with Probiotic yogurt on the level of salivary Streptococci Mutans of dental students of Islamic Azad University in 1390
Purpose
Prevention
Inclusion/Exclusion criteria
Exclusion Factors : Topical Fluoride Therapy ؛ any use of fluoride or antibacterial mouthwashes in the past 3-weeks before the study ؛ any antibiotic therapy two weeks prior to the study ؛ any use of Xylitol-contained products during the study؛ any yoghurt or probiotic products consumption during a week before the study .
Inclusion Factor: a dental student.
Age
No age limit
Gender
Both
Phase
3
Groups that have been masked
No information
Sample size
Target sample size:
30
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Crossover
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics Committee of the Dental Faculty of Islamic Azad University of Tehran
Street address
4 plaque ,Neyestan 10 street ,Pasdaran,Tehran
City
Tehran
Postal code
1946853314
Approval date
2011-11-02, 1390/08/11
Ethics committee reference number
د.687.پ
Health conditions studied
1
Description of health condition studied
level of salivary streptococs mutans
ICD-10 code
ICD-10 code description
Primary outcomes
1
Description
salivary streptococos mutans
Timepoint
one day before any intervention ,one day after any intervention
Method of measurement
culture in mittis salivarius agar
Secondary outcomes
empty
Intervention groups
1
Description
Intervention Study Groups: a group that have been received probiotic yogurt .
Each participantshave been asked to eat 200 cc amount of probiotic yogurt 10 minutes after dinner meal and not to brush their teeth for an hour after that.
Category
Prevention
2
Description
Control Groups1 : a group that have been received conventional yogurt .
Each participantshave been asked to eat 200 cc amount of conventional yogurt 10 minutes after dinner meal and not to brush their teeth for an hour after that.
Category
Prevention
3
Description
Control group2 : a group that did not use any yogurt.
The control group has been asked not to use any yogurt or probiotic products in 3-weaks through the study.
Category
Prevention
Recruitment centers
1
Recruitment center
Name of recruitment center
Dental Faculty of Islamic Azad University of Tehran
Full name of responsible person
Nesa Jamei
Street address
4 plaque ,Neyestan 10 street ,Pasdaran,Tehran
City
Tehran
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Vice chancellor for research ,Dental Faculty of Islamic Azad University of Tehran
Full name of responsible person
Arash Azizi
Street address
4 plaque ,Neyestan 10 street ,Pasdaran,Tehran
City
Tehran
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice chancellor for research ,Dental Faculty of Islamic Azad University of Tehran
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Dental Faculty of Islamic Azad University of Tehran
Full name of responsible person
Nesa Jamei
Position
Student
Other areas of specialty/work
Street address
4 plaque ,Neyestan 10 street ,Pasdaran,Tehran
City
Tehran
Postal code
Phone
+98 61 1337 3843
Fax
Email
nesa_jamei97@yahoo.com
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Dental Faculty of Islamic Azad University of Tehran
Full name of responsible person
Nesa Jamei
Position
Student
Other areas of specialty/work
Street address
4 plaque ,Neyestan 10 street ,Pasdaran,Tehran
City
Tehran
Postal code
Phone
+98 61 1337 3843
Fax
Email
nesa_jamei97@yahoo.com
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Dental Faculty of Islamic Azad University of Tehran
Full name of responsible person
Nesa Jamei
Position
Student
Other areas of specialty/work
Street address
4 plaque ,Neyestan 10 street ,Pasdaran,Tehran
City
Tehran
Postal code
Phone
+98 61 1337 3843
Fax
Email
nesa_jamei97@yahoo.com
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)