The present study has been designed to investigate the effects of pomegranate seed oil (PSO) on insulin resistance, serum concentrations of systemic and vascular inflammatory markers, adipokines and lipid profile in type 2 diabetic patients . it is a randomized, double-blind and placebo-controlled trial .eighty subjects are recruited from an endocrine clinic sequentially and randomly assigned into two groups, the intervention (n =40) and control (n =40) groups.for all of whom demographic data and medical history at baseline will be documented, and subjects will be given capsules containing either PSO or placebo for eight weeks. The intervention group will consume PSO capsules, containing 1000 mg PSO twice daily (2000 mg PSO), while controls will take placebo capsules for eight weeks. Inclusion criteria are: willingness to work ; diabetes type 2 (for 5 to 10 years) ;age between 35 and 65 years; BMI between 20 to30. Exclusion criteria are: supplementation with antioxidant and anti-inflammatory drugs during the past month ;weight loss diets;not medication compliance ; patient with severe hyperglycemia (fasting glucose greater than 250);renal failure ; heart disease and liver failure . At the beginning and end of intervention after 12 to 14 hours of fasting, 10 ml of blood is taken from each patient . HbA1C levels will be measured by ion-exchange chromatography . Insulin, adiponectin, leptin, systemic inflammation, and vascular factors (including IL-6, hs-CRP, sICAM-1, sVCAM-1) will be determined by ELISA, serum triglyceride, total cholesterol, HDL-C and LDL-C will be measured enzymatically using autoanalyzer . Nutrition program and SPSS version 18 will be used respectively for dietary assay and analyzing.