Muscle damage caused by free radicals may be produced during intense exercise. Antioxidants prevent the oxidative stresses induced by intense physical exercise and after exercise helps to go back to initial conditions. Thus, antioxidant supplementation in athletes can be useful. Pomegranate contains a variety of sugars, organic acids, alkaloids, poly-phenols, flavonoids, anthocyanins and vitamins that can be effective in improving the antioxidant capacity. This study investigated the effects of pomegranate juice consumption with endurance exercise on oxidative stress and inflammatory markers and body composition of muscle damage is done. Procedure: in this study, double-blind, placebo-controlled clinical trial to be conducted 30 healthy young men were randomly divided into control and experimental groups of 15 persons. Inclusion criteria: men; willingness to participate in the study; no use of antioxidant supplementation in the past one month; age between 20 to 25 years old and BMI between 20-25. Exclusion criteria: being athlete; smoking; catching diseases that require special treatment; unwillingness to continue the study. Interventions consisted of 250 mL of pomegranate juice naturally matched control group of 250 cc oil pomegranate juice and physical activity to be 3 times a week, each time for 90 minutes of aerobic exercise as running with the intensity of 70% VO2 max is 8 week is done. Before and after intervention in both groups fasting blood sample for testing creatine kinase, lactate dehydrogenase, malondialdehyde, CRP is taken. Body composition parameters measured by the device bioimpedance the results of both groups are analyzed and compared.