Comparison between misoprostol and oxytocine in cervical ripening for labour induction: a randomized clinical trial

1-Objectives: To compare the effect of misopristol and oxytocin in the preparation of the cervix in the induction of labour 2-Design: Randomized, clinical trial, not blinded. 3-How to do: After explaining about labour induction procedures and prepare a written testimonial cervical consciously from the patient and his wife will be getting. Women who enter the entry criteria to fill will be plan . The embryos before the induction of childbirth rate is measured and recorded. Referring to random women in the 95-members will receive oxytocin or misopristol soon as a person to the extent of the contraction phase, optimal heart rate achieved the embryo will be evaluated. In cases of tachysystole (contraction or more over the course of 10 minutes) and hipertone/hypersystole of the uterus (uterine contraction with a duration of over 2 minutes) and in the absence of fetal heart rate changes, the usual way to treat these issues will. In the case of hiperstimulation syndrome or fetal hypoxia, disconnected and induction will be performing a cesarean section. 4- Participants : Entry criteria : Medical indication for the induction of delivery; Single twin pregnancies; Gestational age more than 36 weeks; Vertex presentation ;The normal heart rate of embryos .The exit criteria: The embryo-pelvic dystocia; An estimated weight of over 4000 grams or evidence of a lack of fitness cephalopelvic ; Abnormal vaginal bleeding or any placenta previa; The number of pregnancy over 4; Fetal malformation; Previous uterine scar; Any situation that does not cause vaginal delivery indication, Any contraindication use of misopristol ; Severe polyhydramnios . 5- Interventions: For women who receive misopristol, 50 mcg of medication in posterior vaginal fornix will be placed. The dose every 4 hours to 25 mcg can be repeated up to a pattern of at least 3 contraction in 10 minutes get. The maximum dose of 200 mcg. If this is the contractile pattern up to 4 hours after injection of the seventh dose drug is created, it will be deemed a failure of induction of labour. After acquiring the contractile pattern will not be prescribing other ideal misopristol. For women, group 2 mU/min drug oxytocin for intravenous infusion will be used in intervals of 30 minutes 2 times the amount of the drug, as long as proper contractile pattern. The dose up to maximum 20 mU/min infusion is increased and the limit will be preserved. If desired the contractile pattern up to 15 mU did, failure of induction of delivery will be considered. Even after the acquisition of optimum pattern of contractile administered oxytocin will continue. 6-The main outcome variables: Bishop Index

Ahwaz Jundishapur University of Medical Science, Vice Chancellor for Research and Technology