The effect of curcumin on inflammatory factors؛ lipid profile؛ glycemic index؛ anthropometric indices؛ sonographic finding and liver function in patients with NAFLD. Inclusion criteria: not suffering from diseases such as cardiovascular problems؛ kidney؛ lung؛ thyroid disorders؛ non-smoking and inflammatory drugs like celecoxib. Exclusion criteria: patients with diseases such as cardiovascular problems؛ kidney؛ lung؛ thyroid disorders؛ Are pregnant؛ smoking and drugs like celecoxib inflammation؛ Patients with non-alcoholic fatty liver؛ alcoholic؛ a sample size of 80 intervention trial period 09/15/93 to 11/15/93 outcome: treatment
General information
Acronym
IRCT registration information
IRCT registration number:IRCT2014110511763N18
Registration date:2015-01-18, 1393/10/28
Registration timing:retrospective
Last update:
Update count:0
Registration date
2015-01-18, 1393/10/28
Registrant information
Name
Gholamreza Askari
Name of organization / entity
Isfahan University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 31 1792 2110
Email address
askari@mui.ac.ir
Recruitment status
Recruitment complete
Funding source
Isfahan University School of Nutrition
Expected recruitment start date
2014-10-23, 1393/08/01
Expected recruitment end date
2014-12-06, 1393/09/15
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effect of curcumin on liver function enzymes in patients with NAFLD
Public title
The effect of curcumin in the treatment of NAFLD
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria: not suffering from diseases such as cardiovascular problems; kidney; lung; thyroid disorders and liver problems such as hepatitis; chronic liver disease; nonalcoholic fatty liver disease; Pregnant and milking ; BMW over 25; non-smoking and drugs such as celecoxib on inflammation.
Exclusion criteria: patients with diseases such as cardiovascular problems; kidney; lung; thyroid disorders and liver problems such as hepatitis; chronic liver disease; nonalcoholic fatty liver disease; Become pregnant; smoking and drugs such as celecoxib on inflammation.
Age
From 76 years old
Gender
Both
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
80
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
University of Medical Sciences
Street address
St. thousand acres, Isfahan University of Medical Sciences and Health Services, Headquarters
City
isfahan
Postal code
۷۳۴۶۱-۸۱۷۴۶
Approval date
2014-10-16, 1393/07/24
Ethics committee reference number
393581
Health conditions studied
1
Description of health condition studied
nonalcholic fatty liver
ICD-10 code
76.0
ICD-10 code description
Fatty (change of) liver, not elsewhere classified
Primary outcomes
1
Description
ALT
Timepoint
Before and after study
Method of measurement
Enzymatic photometric
2
Description
AST
Timepoint
Before and after study
Method of measurement
Enzymatic photometric
Secondary outcomes
1
Description
TG
Timepoint
Before and after study
Method of measurement
Enzymatic
2
Description
Tch
Timepoint
Before and after study
Method of measurement
Enzymatic
3
Description
HDL
Timepoint
Before and after study
Method of measurement
Enzymatic
4
Description
LDL
Timepoint
Before and after study
Method of measurement
Fried Wald Equation equation
5
Description
hs-CRP
Timepoint
Before and after study
Method of measurement
Aymynvasy sensitive enzymatic
6
Description
F.B.S
Timepoint
Before and after study
Method of measurement
Enzymatic
7
Description
HBA1C
Timepoint
Before and after study
Method of measurement
Enzymatic
Intervention groups
1
Description
Intervention: curcumin, Capsules, 500 mg orally, once daily for 2 months
Category
Placebo
2
Description
Control: placebo (bass calcium phosphate) Capsules 500 mg orally, once daily for 2 months
Category
Placebo
Recruitment centers
1
Recruitment center
Name of recruitment center
Endocrinology and Metabolism Research Center, S. T.
Full name of responsible person
GholamReza Asgari doctor
Street address
Near the center of Smdyh Tee of St. Khurram S T (S)
City
Isfahan
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Isfahan University of Medical Sciences
Full name of responsible person
GholamReza Asgari doctor
Street address
Street thousand acres, Isfahan University of Medical Sciences and Health Services, Headquarters
City
Isfahan
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Isfahan University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Isfahan University of Medical Sciences
Full name of responsible person
GholamReza Asgari doctor
Position
PhD
Other areas of specialty/work
Street address
Street thousand acres, Isfahan University of Medical Sciences and Health Services, Headquarters
City
Isfahan
Postal code
۷۳۴۶۱-۸۱۷۴۶
Phone
+98 31 3668 0048
Fax
Email
askari@mui.ac.ir
Web page address
www.mui.ac.ir
Person responsible for scientific inquiries
Contact
Name of organization / entity
Isfahan University of Medical Sciences
Full name of responsible person
Gholamreza askari
Position
PhD
Other areas of specialty/work
Street address
Street thousand acres, Isfahan University of Medical Sciences and Health Services, Headquarters
City
Isfahan
Postal code
۷۳۴۶۱-۸۱۷۴۶
Phone
+98 31 3668 0048
Fax
Email
askari@mui.ac.ir
Web page address
www.mui.ac.ir
Person responsible for updating data
Contact
Name of organization / entity
Isfahan University of Medical Sciences
Full name of responsible person
Gholamreza askari
Position
phd
Other areas of specialty/work
Street address
Street thousand acres, Isfahan University of Medical Sciences and Health Services, Headquarters
City
Isfahan
Postal code
۷۳۴۶۱-۸۱۷۴۶
Phone
+98 31 3668 0048
Fax
Email
askari@mui.ac.ir
Web page address
www.mui.ac.ir
Sharing plan
Deidentified Individual Participant Data Set (IPD)