Effect of combined supplementation Coenzyme Q10 with L-carnitine on mitochondrial metabolic disorders markers and migraine symptoms among patient with migraine by following a tyramine-controlled diet.

Evaluation the impact of combined supplementation Coenzyme Q10 with L-carnitine on mitochondrial metabolic disorders markers and migraine symptoms among patient with migraine

we will enroll 56 eligible patients with migraine aged 20- 49 years that will be recruited from Imam Mousa Sadr Clinic will randomly assigned into treatment and placebo groups.

The present study is a double-blind randomized clinical trial study and participants, researcher, and statistical analyser will not know from assigned intervention. The population includes 56 patients with migraine that will be recruited from Imam Mousa Sadr Clinic. The participants will randomly assigned into treatment and placebo groups to receive Coenzyme Q10 with L-carnitine or placebo tablets for 8 weeks. migraine symptoms, depression and biochemical assessment will be measured at the beginning and end of each phases.

patients with migraine (with or without aura), both sex, nonpregnant, nonlactative, nonsmokers, non-alcoholic and willing to participate in the study/contain history of chronic diseases, chronic tension-type headache or secondary headaches.

The treatment group will receive 30 mg/day Coenzyme Q10 with 250 mg/day L-carnitine at the same time for 8- weeks and subject in the other group also will receive the placebo tablets. Individuals in both group will receive a list of tyramine contains foods and will be asked not to consume any of these foods during the study.

Migraine symptoms ( severity , frequency and average duration of migraine attacks), Serum Lactate.

Isfahan University of Medical Sciences

In present study, simple randomization method will be used. The randomization unit is individually and we will use the random number table method for random sequences. A random numbered table is a collection of numbers that are without a specific pattern, completely random and as table. The next step is allocation concealment and will use sequentially numbered, sealed, opaque envelopes. Then, based on the sample size, number of envelopes with aluminum surface are provided and each random sequence created on a card and the cards are inserted into the envelopes, respectively. At the time of registration for the participants, according to eligible participants, one of the envelopes is opened and the allocated group for participants is revealed.

The present study is a double blind method and participants, researcher, and statistical analyser will not know according to assigned intervention.