We complete a randomized, double-blind study over 50 trauma patients who have isolated diaphysial long bone fracture in emergency department of Hasheminejad hospital in Mashhad, Iran. Inclusion criteria are the age between 15 and 60 years old; isolated diaphysial long bone fracture without decrease level of consciousness and without any other painful lesion. Participants are offered verbal information about the study as well as a written information sheet. Written informed consent is then obtained. The baseline data collected are: name, sex, age, body weight and the type of the fracture. Adverse reactions are recorded also at the end. Then one of two drugs-morphine sulfate or intravenous acetaminophen is chosen by the randomized block method for any patient. Before administration of chosen drug, our colleague (who is not aware of which drug has been chosen) asks the patient to determine his or her pain severity on the visual analogue scale. It should be noted the patient does not know that which drug has been chosen. Then the patient in morphine sulfate group receives 0.1 mg /kg of intravenous morphine sulfate by researcher. Again the researcher’s colleague asks the patient to determine the pain level based on visual analogue scale 5 and 30 minutes after drug administration. Similarly the patient in acetaminophen group receives 15 mg /kg of intravenous acetaminophen by researcher and is asked by researcher’s colleague to determine the pain severity based on visual analogue scale 5 and 30 minutes after injection. Finally, data will be compared and analyzed.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT2012123111956N1
Registration date:2014-11-12, 1393/08/21
Registration timing:registered_while_recruiting
Last update:
Update count:0
Registration date
2014-11-12, 1393/08/21
Registrant information
Name
Morteza Talebi Doluee
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 51 3852 5312
Email address
talebidm@mums.ac.ir
Recruitment status
Recruitment complete
Funding source
Mashhad University of Medical Sciences
Expected recruitment start date
2014-04-04, 1393/01/15
Expected recruitment end date
2014-11-21, 1393/08/30
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
A comparison between analgesic effect of intravenous acetaminophen vs intravenous morphine sulfate for isolated diaphysial long bone fractures
Public title
A comparison between analgesic effect of intravenous acetaminophen vs intravenous morphine sulfate for bone fractures
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion: dyaphisial fracture of long bone; no decrease level of consciousness; age between 15 to 60 years old.
Exclusion criteria: decrease level of consciousness; any history of renal or hepatic disease; any other painfull lesion; any history of opium addiction.