Comparison of the effect of ketorolac and paracetamol on post operative pain in patients undergoing lower limb orthopedic surgery

The aim of this study is comparing the effects of Ketorolac and Paracetamol on post-operative pain in lower limbs orthopedic surgeries. This is a randomized double blind clinical trial on 96 patients who are candidate of lower limbs surgery. Inclusion criteria: ASA classification I and II; age 18 to 65 years. Exclusion criteria: pregnancy; history of heart failure; kidney diseases; coagulation disorders; uncontrolled blood pressure. In this study 96 patients are included which be divided in 3 groups by simple sampling method (using randomized numbers table). The patients and observers (researchers) are blind to groups’ members. The participants are become familiar with the principle of visual analogue scale (VAS). The VAS of patient is evaluated before induction of anesthesia. The method of anesthesia is similar for all groups. Ten minutes before induction 30 mg ketorolac, 1gr paracetamol and, normal saline is administered in group 1, 2 and 3 respectively. In order to inhibition of narcotics interference with patient’s VAS in recovery room, no administration of fentanyl is done, 30 minutes to the end of anesthesia. In recovery room, VAS of the patient is obtained 45 minutes after patient’s consciousness. At the end of recovery period, the scores of VAS with all demographic information of the patients in all groups are documented and analyzed by statistic software and the effect of ketorolac and paracetamol on post-operative pain in lower limb surgeries is compared with each other.

Vice Chancellor for research of Kerman University of Medical Sciences