Comparison effect of intravascular administration of colloid versus crystalloid in prevention of hypotension after spinal anesthesia for cesarean section

purpose: Comparison of fluid therapy and its effect on the prevention of maternal hypotension in pregnant women ASA I-II who are under spinal anesthesia for elective cesarean section. Design and criteria: This study is prospective, randomized, not-blinded and clinical trial. Setting and conduct: 100 patients scheduled for elective cesarean section under spinal anesthesia were randomly placed into four groups. 7 cc/kg colloid is given before and colloid with spinal anesthesia in group 1 and 2 , respectively, 10 cc/kg of crystalloid is given before and colloid with spinal anesthesia in group 3 and 4 , respectively. Vital signs are checked befor and every 3 minutes to initial 10 minutes after spinal anesthesia and then every 5 minutes until recovery. Inclusion criteria: Candidates for elective cesarean surgery; ASA I-II; 18-40 years old. Exclusion criteria: Patients who received intravenous fluids before entering the operating room; BMI≥30; ASA>3; Age less than 18 years and more than 40 years; Contraindications to spinal anesthesia procedures; Emergency cesarean section; Amount of intraoperative bleeding over 1000cc; History of hypertension and blood pressure in pregnancy; instances may increase the risk of bleeding and inertia. Main outcome: Primary outcomes; blood pressure and heart rate changes. Secondary outcomes; nausea & Vomiting, Chest discomfort, neonate apgar, Efedrin require. Intervention: Group1 ; Colloid recipient, 20 min before spinal anesthesia. Group 2 ; receiving Colloid while spinal anesthesia. Control group 1 ; Crystalloid recipient, 20 min before spinal anesthesia. Control group 2 ; Received spinal anesthesia with crystalloid.

Vice Chancellor for Research, Mashhad University of Medical Science