Comparison of the effect of ketorolac, paracetamol and saline on the pain and the need for morphine in patients undergoing surgery via video thoracoscopy

The purpose of this study is comparison of the effects of Ketorolac, paracetamol and saline on the pain and the need for morphine in patients undergoing surgery via video thoracoscopy. This study is a randomized double-blind, placebo-controlled, and will be done on 93 patients candidates for video thoracoscopy surgery and are classified as class 1 to 3 of the Anesthesia Association of America, and do not have any history of heart failure or kidney failure or uncontrolled systemic disease. The patients receive the same anesthetic and sedation and , the patient transfer to the recovery room after the surgery and at that time the patients immediately undergo intravenous injection with paracetamol (apotel), Ketorolac and normal saline. The patients in the first 24 hours after surgery are under drug infusion. GroupA receives ketorolac,and group B receives Apotel and group C receives only saline in 24 hours. Patient pain intensity will be assessed with using a visual analogue scale rating of zero (no pain) to 10 (worst pain imaginable). Mean arterial pressure, heart rate and arterial oxygen saturation will be recorded at this time too. At the end the amount of morphine of the three groups will be compared. Complications such as bleeding in the first 24 hours after surgery, respiratory distress will recorded also.

Deputy for Research and Technology Shahid Beheshti University of Medical Sciences