After obtaining written informed consent from the patient's family, and getting an approval from Ethics committee of Ahvaz Jundishapur University of Medical Sciences, 40 head trauma patients will take part in a single-blind prospective, randomized study to comparative efficacy of Cyproheptadine and Baclofen on spasticity in patients with head trauma. Inclusion criteria: patients with diffuse axonal injury without chronic hepatic or renal disease; 15 to 60 years old. Exclusion criteria: changing in treatment plan like surgery; drug reactions; drug side effects. Patients will be randomly allocated into two groups according to table of random numbers. Groups "one" and "two" will receive oral Cyproheptadine 2 mg/kg with oral Baclofen 25 mg/kg and oral Baclofen 25 mg/kg every eight hours for fifteen days, respectively. Both groups of patients are unaware of type of prescription drugs. Spasticity in patients in 1, 3, 6, 9, 12, 15 days, according to Modified Ashworth Scale is measured. Alaninetransaminase, Aspartate Aminotransferase, and Alkaline Phosphatase weekly, and Blood Urea Nitrogen, and Creatinine daily will measure.