The purpose of this study was to compare oral and vaginal misoprostol in pregnant women who referred to Besat Hospital of Sanandaj in 1393 for legal abortion. Total of 70 pregnant women that with Legal Medicine permission were referred to Besat Hospital of Sanandaj in order to pregnancy termination were selected. Inclusion criteria included pregnant women who were candidates of pregnancy termination with the permission of legal Medicine and exclusion criteria were pregnant women who were breastfeeding, women with severe liver disease, chronic pulmonary disease, Mitral valve stenosis, history of allergy to prostaglandins, inflammatory disease of intestines, asthma, glaucoma, hypertension, and severe bleeding. After obtaining written informed consent they were randomly divided into 2 oral misoprostol and vaginal misoprostol groups using 2 block method and table of random numbers. In oral group 200 micrograms of misoprostol was used every 6 hours up to 6 times up to 36 hours and also in vaginal group 200 micrograms of misoprostol was used every 6 hours up to 6 times up to 36 hours. To double blind the study placebo was used. In oral group, vaginal placebo and in vaginal group oral placebo was used simultaneously. Researcher and the participants in the study were not aware of the drug or placebo. At the end of the study, the efficacy of treatment method namely the rate of pregnancy products excretion and complications (bleeding, fever,uterus perforation) were measured in both groups.