The aim of this study is to compare pregnancy rates of exogenous protocols and ovarian stimulation Protocols with natural protocol in women undergoing receiving blastocyst embryo freezing.
In this randomized clinical trial, 150 patient with inclusion criteria (all healthy women 18 to 40 years, etc.) And exclusion criteria (sever Endometriosis, etc.) are selected. No drug is given for the control group (natural).
While follicles reach to 18-20 mm, shape and thickness of the endometrium are noted. After 36-38 hours ovulation is confirmed by vaginal ultrasound and in 4 days blastocyst is transferred.
In the first intervention experimental group (Stimulation), patients are taken Clomiphene Citrate tablets
100 mg daily from the fifth day to the ninth day of the cycle.
While follicles reach to 18-20 mm, shape and thickness of the endometrium are noted. After 36-38 hours ovulation is confirmed by vaginal ultrasound, and blastocyst is transferred in 4 days.
In the second intervention experimental group (Artificial), from the third day of the cycle, Estradiol vale rate tablets 6 mg is given per day. When the endometrial thickness is greater than 8 mm, the shape and thickness of the endometrium is noted. From this special day, 100 mg injection of progesterone along with Estradiol is given daily. Five days after starting progesterone, blastocyst is transferred. If the endometrial thickness doesn't get more than 8 mm in 15th day, Estradiol dose will be increased to 8 mg. In this method, the progesterone as a support would be continued till clarifying the pregnancy test in consistency with getting positive of pregnancy test until sixth week to eighth week of pregnancy.
At the end, the primary outcome, number of pregnancies and abortions done in the artificial and stimulation protocols with natural protocol in women undergoing freeze blastocyst transfer are compared. Hence, secondary outcome, endometrial thickness and shape in two protocols Stimulation and artificial with natural protocol are compared as well.