Assessment of local bupivacain injection effect in comparison of placebofor relieving of acute post - thoracotomy pain in patients who undergoing thoracotomy.

Objectives: The aim of this study is to evaluate the effect of local bupivacaine which inject at the incision line before surgery in the management of pain after thoracotomy surgery. Study Design: In a randomized, double-blind clinical trial all patients who candidate for thoracotomy divide into two groups (case and control). Setting and conduct: Patients enroll in the study after written informed consent, complete history take and all subjects undergo physical examination and preoperative evaluation. All patients receive general anesthesia and surgical procedures are the same for all, intercostals blocks perform at the end of the operation for all patients. A person who inject and nurses do not know about patients' group, so patients receive analgesics as routine and its amount will be recorded. Participants, inclusion and exclusion criteria: All patients who candidate for elective thoracotomy enroll. Inclusion criteria: Patients age between 10 to 70 years old. Exclusion criteria: drug addictions and chest pain in previous history. Interventions: In the first group after anesthesia and before thoracotomy incision, 2mg/kg bupivacaine 0.5% diluted by distilled water inject subcutaneously around the site of the incision line, so that infiltrate the entire length of the incision. In control group a placebo (normal saline 0.9%) will inject as same volume and same way which is performing for patients group. The main outcome variables: The main outcome variables are severity of pain and need to analgesics.

Vice Chancellor for Research of Semnan University of Medical Sciences