Comparison of the effect of Acetaminophen and Ibuprofen in pain relief and complication management following Adenotonsillectomy in 4-10 year old children.

The main objective of this study is to determine the difference between Acetaminophen and Ibuprofen in pain relief following Adenotonsillectomy in children. The study has been designed as a Randomized Clinical Trial which is triple blind with no placebo control group in a single research center.Population which has been chosen as our study instant children are, belong to the range of 4 to 10 years old groups. Inclusion criteria: 1. No Allergy to Non Steroid Anti-Inflammatory Drugs 2. No History of coagulopathy 3. No Renal or Hepatic disorder 4. No Severe Asthma (recently admission or treatment with oral corticosteroid) 5. No Family history of coagulopathy 6. No Evidence of Mental retardation Exclusion criteria: 1. Severe and uncontrollable bleeding during and after surgery 2. Severe pain after surgery which needs additional analgesic Sample size is 50 individuals that are randomly assigned them to two equal groups. Intervention in each group is defined as either administration of Acetaminophen or Ibuprofen . The outcomes of study are: 1. Pain score after surgery ( after 6 hours postoperative, after 24 hour, after 48 hour ) 2. The number of episodes of nausea and vomiting after surgery ( during first day, during first week ) 3. Intraoperative bleeding volume 4. Postoperative bleeding ( during first day, during first week ) 5. Time to start eating of oral liquids, semisolid and solid foods 6. Time to going back to their normal life 7. Overall satisfaction of recovery

Vice chancellor for research, Tehran University of Medical Sciences