Evaluation of the Effect of Intratracheal Furosemide, Salbutamol, or a Mixture of Both with Surfactant on Clinical Course of Premature Infants with Respiratory Distress Syndrome

The purpose of this study is to investigate the effect of intratracheal administration of Furosemide, Salbutamol, or a mixture of both with Surfactant on the clinical course of premature infants with respiratory distress syndrome.Inclusion criteria: gestational age less than 34 weeks; respiratory distress syndrome and exclusion criteria: body weight less than 1000 g; congenital anomalies; birth trauma and perinatal asphyxia. Newborns with body weight less than 1500g with respiratory distress syndrome initially would be treated with NCPAP and 50% oxygen concentration. Base on the arterial blood gas analysis the newborns would be intubated, surfactant given and NCPAP continue or mechanical ventilation considered. Newborns with body weight greater than 1500g with respiratory distress syndrome initially would be treated with 40% oxygen concentration. If respiratory distress increases, NCPAP would be started and oxygen concentration increased up to 50%. Unresponsive patients would be intubated, surfactant given and NCPAP continue or mechanical ventilation considered. This is a double blind pilot study and 48 premature newborns with respiratory distress syndrome who need to surfactant would be enrolled in the study. Base on the table of random numbers beside of surfactant one of the following compound would be administered intratracheally: A (Furosemide), B (Normal Saline), C (Salbutamol), D (Furosemide and Salbutamol). Duration of NCPAP treatment, need to mechanical ventilation and its duration, duration of need to oxygen and days of admission would be assessed between four groups.

Ahvaz Jundishapur University of Medical Sciences