The efficacy of use and without use of Rosa damascene extract in treatment of sexual dysfunction induced by Selective Serotonin Reuptale Inhibitors in men with Major Depressive Disorder

The purpose of this study is to evaluate the efficacy of Rosa damascenes extracts in the treatment of sexual dysfunction induced by serotonin reuptake inhibitors in men with major depressive disorders. This is a triple-blind clinical trial.60 married men referred to Kermanshah Farabi Hospital were selected and randomly divided into two groups. The intervention group received 3 cc Rosa damascenes drop daily for 8 weeks which was equivalent to 17 mg citronellol. The control group received 3 cc distilled water (placebo) daily. Then at the beginning of the study, fourth and eighth week of the study, libido and sexual level, erection times, hardness and stiff of erection, hardness of flow out of semen, the problem of amount and flow out of semen, lack of libido, the problem of become erect and keeping it, and sexual satisfaction were examined. Inclusion criteria: Patients with major depressive disorders; and those who had been treated with a fixed dose of serotonin reuptake inhibitors for at least eight weeks; those who haven’t sexual disorder before begin the treatment and they affected sexual disorder with use of this medicines Exclusion criteria: presence of sexual dysfunction before taking serotonin reuptake inhibitors; presence of any systemic or psychiatric disorders , Thyroid disease and hyperprolactinemia or taking any medication which affects sexual activity; any history of drug or alcohol use during 6 recent months; those who have recently had significant changes in sexual activity due to their wife pregnancy, remarriage and divorce.

Kermanshah University of Medical Sciences