The main goal of this study is to determine locally effect of Cyclosporine and Dexametasone seprately and in combination with decreased dosage in oral lichen planuse management and evaluate the side effects.
This study is randomized, double blind clinical trial and patients select according to inclusion and exclusion criteria
Inclusion criteria ; Patients with oral lichen planus diagnosed according to modified WHO ; Painful lesion (VAS = 3-7 )
Exclusion criteria
Patients with systemic disease :hypertension, pulmonary disease ,kidney disease , severe heart disease , chronic liver disease, uncontrolled diabetes ; pregnant or breast feeding patients and patients who take sterogene based drugs ; Patients who were under local or systemic agents for lichen planus with in two previous months ; Patients with history of cancer and using immunomodulating drugsin last two months ; oral lichen planuse concurrence with skin lesion or other mucosal lesion ; Patients who take beta blockers ,diuretics, anticonvulsants, barbiturates and ACE inhibitors ; Patient with complete denture.
Sample size (36)consists of three groups of 12 patients ,Group 1: Dexamethasone 0.1%,Tid,5ml
Group2: Cyclosporine 0.1%,Tid,5ml
Group3: Dexamethasone 0.05 % + Cyclosporine 0.05 % ,Tid,5ml
after oral examinations and recording clinical scoring and visual analogue scale they will be given mouth wash weekly for 6 weeks.