Nigella sativa (N. sativa) seed is a commonly used herb which has been shown to possess in vitro antihelicobacter activity. The objective of the study is to evaluate the efficacy of N. sativa seeds in eradication of H. pylori infection in non-ulcer dyspeptic (NUD) patients. The study will be conducted on 110 adult patients, both sexes with the age range of 18-65 years, attending the Gastroenterology Division of the Department of Medicine, King Fahd Hospital of the University, AlKhobar, Saudi Arabia from March 2007 to August 2008. Patients complaining of dyspeptic symptoms and found positive for H. pylori infection as confirmed by histopathology and urease test will be included in the study. Those suffering from peptic ulcer, gastric cancer or other gastrointestinal bleeding as seen during endoscopy; or who have taking proton-pump inhibitors, bismuth or antibiotics in the last 4 weeks before endoscopy; or pregnant or lactating, or intolerant to therapeutic regimens will be excluded from the study. Approval from ethics committee and written consent from patients will be obtained. Patients will be randomly assigned to four groups, receiving: Triple therapy (clarithromycin, amoxicillin and omeprazole), 1g N. sativa and 40mg omeprazole, 2g N. sativa and 40mg omeprazole, or 3g N. sativa and 40mg omeprazole. Negative H. pylori stool antigen, 4 weeks after end of treatments will be considered as eradication. We hope that N.sativa will be a useful cheap and easily available alternate/adjunct treatment for the eradication of H.pylori.