This interventional study- outcome based- aimed to assess the impact of nursing care educational program on the outcome of mechanical ventilation in infants undergoing mechanical ventilation in the NICU, and secondary objectives is comparison of the frequency of the most common consequences of mechanical ventilation in neonate, including ventilator-associated respiratory infections, bronchopulmonary dysplasia, pulmonary hemorrhage, retinopathy of prematurity, etc. Research environment is NICU of Comprehensive Women's Hospital (Mirza kouchak Khan) in Tehran. The study population is all infants admitted to the intensive care unit of this hospital and undergoing ventilation from Farvardin 1392 to Farvardin 1393. Inclusions Criteria are admitted discharged or died infants undergoing mechanical ventilation in this interval. All newborns undergoing mechanical ventilation due to asphyxia, congenital anomalies and pulmonary hypoplasia, who have less than 6 hours of mechanical ventilation, and Mid-treated infants who have been separated for any reason from ventilator, have been Excluded. This project is a four-step method. Firstly, to collect demographic information and the consequences caused by the use of mechanical ventilation from infants admitted to the NICU. In the second step (the start of the intervention) guidelines for the care of the infant undergoing ventilation, are provided for NICU nurses. In the third step, Participatory and Questions and Answers training session about care will be held by researchers and professors during specific hours. The final step of the study is conducted, with a time interval of 1 month after completion of the education. In this point, neonatal records infants are investigated to collect information for 6 months. Finally, by comparing the data obtained through statistical tests, results will be announced. The main variables in this study include educational program of nursing care and outcome of mechanical ventilation.