Effective Desensitization to wheat for allergy with Wheat in cases 2-18 age for 1 year in Allergy and Immunology clinic in Rasul Akram hospital. Inclusion criteria: 1-patients with type one hypersensitivity reaction to wheat. 2-patients age ranging from 2-18 years old. 3-patients without cardiac diseases (heart failure, heart valve insufficiency, severe valve stenosis, myocardial infarction). 4-patients without severe pulmonary diseases (severe asthma, chronic obstructive pulmonary disease, severe chronic bronchiolitis). 5-informed consent was taken for including the patient in the study. 6- Not having any other chronic disease. Exclusion criteria: 1-patients who did not permit us to enter them in the study. 2-patients with hypersensitivity reactions other than type one reaction. 3-patients having cardiac diseases (heart failure, heart valve insufficiency, severe valve stenosis, myocardial infarction) 4- patients with severe pulmonary diseases (severe asthma, chronic obstructive pulmonary disease, severe chronic bronchiolitis). 5-patients age less than 2 or more than 18 years old. There are 5 patients entering our study, for whom skin prick testing, serum total and specific IgE level, complete blood cell count and nasal smear was done before and after protocol. Desensitization protocol was started with small doses of dose semolina flour and the dose was increased slowly during seven months until reaching total dose of 4.5 grams of semolina powder, and then desensitization was continued with pasta from one piece of pasta per day to 100 pieces of pasta (60 grams) per day. During the study patient stays under allergy subspecialist observe and in the hospital and stays in the hospital until 2 hours after desensitization in every session, and resuscitation equipment is available during desensitization. if patient develops severe allergic reactions during desensitization (respiratory distress, severe dyspnea, systolic hypotension more than 30% from baseline or less than 90 mmHg, cardiac arrhythmia, generalized urticarial or anaphylactic reaction, desensitization will be discontinued. If patient tolerates the desensitization protocol or just develops mild reactions such as urticarial, skin rash, mild wheezing, or weakness and ... the patient will continue the desensitization protocol and during 4 months patient will tolerate maximum semolina flour dose and enters the second course of desensitization. In the second course, we start from pasta (wheat flour) from small doses and during 7 months the dose will reach maximal dose of 100 pieces of pasta. there are 5 patient who enter the protocol. major goals: taking any amount of wheat in patients. Minor goals: to determine serum total IgE level in patients with sensitivity to wheat flour before desensitization, 2-determination of serum total IgE levels in patients after beginning of desensitization. 3- determination of eosinophilia in CBC of patients before desensitization.4- determination of eosinophilia in CBC of patients after desensitization.5-determination of skin prick testing results in patients before desensitization.6- determination of skin prick testing results in patients after desensitization 7- determination of nasal smear results before desensitization. 8- Determination of nasal smear results after desensitization. Clinical purposes: 1-making tolerance in taking wheat flour in patients with immediate type hypersensitivity reactions (type1) and prevention from anaphylactic reactions. 2-improving quality of life and eliminating limitations in nutrition in patients with immediate type hypersensitivity reactions (type1). Major variables: allergy and reaction to wheat in patients. Secondary variables: blood eosinophilia, nasal smear eosinophilia, serum total IgE levels, serum wheat specific IgE levels, skin prick test.