Comparison the sedative effect of intranasal administration of midazolam and Dexmedetomidine in uncooperative 4 to 6 years of age pediatriientsc dental pat

The aim of this study is to compare the effectiveness of two sedative agents including Intranasal Midazolam and Dexmedetomidine among uncooperative pediatric dental patients. The double blind randomized study will be conducted in parallel groups. The study participants include one hundred healthy( ASA I) uncooperative 4 to 6 years of age dental patients who are refereed to specialized clinic of Pediatric Dentistry of Guilan Dental School who are and behavior are classified Negative or Definitely Negative(scores 1 and 2) according to Frankl Behavioral Scale. Those children with a history of allergic reactions to any of above mentioned agents or any other sedatives, as well as history of sleep apnea, delayed growth or mental retardation, any previous adverse reaction to sedation or general anesthesia, and those children who refuse to accept the drug administration, and who have a history of upper respiratory infection or nasal secretion during the past two weeks will be excluded from study. The participants are randomly assigned in to one of two experimental groups to receive either midazolam 0.2 mg/kg or Dexmedetomidine 1µg/kg. Sedation status will be evaluated using Houpt Sedation Rating Scale from aspects of Sleep, Crying, Movement and Overall sedation status. Vital signs including Oxygen saturation (SPo2), Heart Rate, Blood Pressure, and Respiratory Rate are recorded before drug administration and then the child will be transferred to dental chair after 15 minutes. The Vital signs will be recorded again at beginning of the treatment and then every 15 minutes until the end of treatment.

Grant from research commitee of Guilan University of Medical Sciences