Objective: Comparison of analgesic effect of interavenous Lidocaine versus Fentanyl
Design: During a prospective double blinded study, the patient of 18-65 years old with pain of renal colic nature referred to Emergency Department were included in the trial. For the women of fertility age pregnancy test applied to rule out pregnancy. The Sample size was 40 patients, which randomized in a double blind study in one hospital center.
Setting and Conduct:Electrocardiogram has been arranged and interpreted for patients to confirm there is no concurrent dysrhythmia or ischemic heart disease. Then the patients have been randomized in a double blind study of 2 groups. For first group intravenous bolus dose of lidocaine of 1.5 mg/kg during 2 minutes were administered and the second group intravenous fentanyl with bolous dose of 1.5 microgram/kg under cardiac monitoring with responsibility of an Emergency Medicine specialist. Patients symptoms such as vital signs, nausea, vomiting were evaluated and pain score of arrival, 5, 10, 15 and 30 were recorded based on visual analog scale. Patient consent form was signed and the course of the study was described for all patients. The patients whom have pain after 30 minutes of trial will receive 0.1 mg/kg as an adjunctive pain killer. Renal pain diagnosis in both groups will confirm with sonography or spiral CT scan and hematuria in urine analysis. The patients with unconfirmed diagnosis will omit from the study. All questionnaire data will collect by one operator who is not aware of the prescribed drug to avoid any bias. The results will statistically analyze and drug analgesic effect will evaluate with Mann Whietney test using SPSS software.
Participant including major eligibility criteria: Renal colic patients between 18-65 years old which had no history of ischemic heart disease and dysrhythmia and hepatic and renal disease and no history of Monoamine oxidase inhibitor and no sensitivity to lidocaine and opioids.
Intervention: For first group intravenous bolus dose of lidocaine of 1.5 mg/kg during 2 minutes were administered and the second group intravenous fentanyl with bolous dose of 1.5 microgram/kg under cardiac monitoring with responsibility of an Emergency Medicine specialist. Patients symptoms such as vital signs, nausea, vomiting were evaluated and pain score of arrival, 5, 10, 15 and 30 were recorded based on visual analog scale.
main outcome measures : Pain Score