Protocol summary

Summary
This is an interventional study.Goal of study is comparing hearing improvement in patients with otosclerosis who underwent primary stapedotomy with teflon-piston or softclip prosthesis . This is a randomized controlled trial in a single center (Dastgheib hospital) which is not blind. Statistician does not know which prosthesis was used for each patient. Study population is 120 patients divided in two groups by block randomization; 63 patients in teflon piston group and 57 patients in soft clip group. Inclusion criterion: Patients who suffered from otosclerosis and undergone stapedotomy with each of prosthesis as intervention. Exclusion criteria: Patients, who underwent stapedectomy and/or revision stapedotomy, Patients who underwent stapedotomy for reasons other than otosclerosis, patients with inadequate postoperative follow-up. preoperative physical exam and audiometry will be done for all patients. All operations will be done by one surgeon,under local anesthesia, and with transcanal approach. Patients will be followed at least 6 months.Data gathering will be done between july 2015 and july 2016. In 6 months postoperative follow up physical exam and audiometry will be done. Preoperative and postoperative air conduction (AC) and bone conduction (BC) values at 500,1000,2000,3000 Htz will be recorded. Air-bone gap will be calculated. Speech reception threshold (SRT) and speech discrimination score (SDS) is recorded too.To compare hearing improvement in two group as primary outcome, these preoperative and postoperative audiometric findings will be compared.

General information

Acronym
IRCT registration information
IRCT registration number: IRCT2014012115496N5
Registration date: 2015-09-11, 1394/06/20
Registration timing: registered_while_recruiting

Last update:
Update count: 0
Registration date
2015-09-11, 1394/06/20
Registrant information
Name
Sareh Roosta
Name of organization / entity
Vice Chancellor for Research and Technology, Shiraz University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 71 3612 5323
Email address
namazi_balini@sums.ac.ir
Recruitment status
Recruitment complete
Funding source
shiraz university of medical science
Expected recruitment start date
2015-06-22, 1394/04/01
Expected recruitment end date
2016-06-21, 1395/04/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Comparison hearing result between fluoroplastic (Teflon) Causse Loop Piston and titanium Soft Clip in patient underwent stapedotomy in 2015 in Dastgheib university Hospital
Public title
comparing hearing result between two prosthesis teflon-piston and softclip
Purpose
Treatment
Inclusion/Exclusion criteria
inclusion criteria:patients who suffered from otosclerosis and underwent stapedotomy with fluoroplastic (teflon) Causse Loop Piston prosthesis or titanium soft clip. exclusion criteria:: 1) All Patients who underwent stapedectomy; 2) Revision cases; 3) Patients who underwent stapedotomy for reasons other than otosclerosis, such as: congenital stapes fixation, malleus head fixation, trauma, chronic otitis media, and tympanosclerosis plaque; 4) Inadequate follow-up(less than 6 months) after surgery.
Age
No age limit
Gender
Both
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size: 120
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
ethics committee of Shiraz University of Medical Sciences
Street address
Shiraz University of Medical Sciences, Zand Street, Shiraz, Fars, Iran, Islamic Republic
City
shiraz
Postal code
713451978
Approval date
2015-06-10, 1394/03/20
Ethics committee reference number
IR.sums.med.rec.1394.18

Health conditions studied

1

Description of health condition studied
otosclerosis
ICD-10 code
H80.0
ICD-10 code description
Otosclerosis involving oval window, nonobliterative

Primary outcomes

1

Description
ABG(air-bone gap)
Timepoint
preoperative and 6 month postoperative
Method of measurement
audiometery(gap between air and bone conduction)

2

Description
SRT(speech reception threshold)
Timepoint
preoperative and 6 month postoperative
Method of measurement
audiometery

3

Description
SDS(speech discrimination score)
Timepoint
preoperative and 6 month postoperative
Method of measurement
audiometery

Secondary outcomes

empty

Intervention groups

1

Description
stapedotomy with Flouroplastic(teflon) causse loop piston prosthesis in intervention group 1
Category
Treatment - Surgery

2

Description
stapedotomy with titanium soft clip prosthesis in intervention group 2
Category
Treatment - Surgery

Recruitment centers

1

Recruitment center
Name of recruitment center
shahid dastqeib hospital
Full name of responsible person
mohamad faramarzi , otolaryngologist , fellowship of otology , fellowship of rhinology and sinus
Street address
next to melli garden ، hafez avenue ، Shiraz
City
shiraz

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Vice chancellor for research Shiraz University of Medical Sciences
Full name of responsible person
Basir Hashemi
Street address
Shiraz University of Medical Sciences , Zand Avenue , Shiraz
City
shiraz
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice chancellor for research Shiraz University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty

Person responsible for general inquiries

Contact
Name of organization / entity
Vice Chancellor for Research of Shiraz University of Medical Sciences
Full name of responsible person
Basir Hashemi
Position
otolalaryngologist
Other areas of specialty/work
Street address
Shiraz University of Medical Sciences , Zand Avenue , Shiraz , Iran
City
shiraz
Postal code
71348-14336
Phone
+98 71 3235 7282
Fax
Email
vcrdep@sums.ac.ir
Web page address
research.sums.ac.ir

Person responsible for scientific inquiries

Contact
Name of organization / entity
Shiraz University of Medical Science
Full name of responsible person
Mohamad Faramarzi
Position
otolaryngologist , fellowship of otology , fellowship of rhinology and sinus
Other areas of specialty/work
Street address
Shiraz University of Medical Sciences , Zand Avenue , Shiraz , Iran
City
Shiraz
Postal code
71348-14336
Phone
+98 713230541019
Fax
Email
faramarzi@sums.ac.ir
Web page address

Person responsible for updating data

Contact
Name of organization / entity
shiraz university of medical science
Full name of responsible person
Nafiseh Gilanifar
Position
otolaryngology resident
Other areas of specialty/work
Street address
shiraz university of medical science-zand avenue-opposite the palestine avenue-Shiraz
City
shiraz
Postal code
71348-14336
Phone
+98 713230541019
Fax
Email
nafisehgilanifar@yahoo.com
Web page address

Sharing plan

Deidentified Individual Participant Data Set (IPD)
empty
Study Protocol
empty
Statistical Analysis Plan
empty
Informed Consent Form
empty
Clinical Study Report
empty
Analytic Code
empty
Data Dictionary
empty
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