The study investigates effect of the extract of Cichorium intybus root in reducing the alaninThe study investigates effect of the extract of Cichorium intybus root in reducing the alanine aminotransferase level and compares it with the placebo in patients with non-alcoholic fatty liver disease. This study is a randomized double-blind clinical trial. A number of 60 people were selected for the study. Inclusion Criteria: age from 18 to 70 years; fatty liver disease grade 1, 2 or 3 diagnosed by ultrasound; No current use of another drug for fatty liver treatment which has not been taken before. Exclusion Criteria: Advanced cardiovascular disease, pulmonary or renal disease; Pregnancy; Breast feeding; Allergy to Cichorium intybus; Non-compliance with medication; Psychiatric diseases complicating the results evaluation or causing patient’s lack of cooperation; Advanced cirrhosis , Hepatitis and other liver diseases except non-alcoholic fatty liver; alcohol consumption by patients; Fatty acid oxidation disorder ( congenital );Patients with diabetes who are treated with insulin. The duration of intervention is two months, where in the Intervention 1 Cichorium intybus root extract, and in the Intervention 2 corn starch. Duration of intervention: 2 months case 1: chicory root case 2: corn starch Before and after taking the drug, Alanine aminotransferase ,Fasting blood sugar, Total cholestrol,Triglycerides,High-density lipoprotein, Low-density lipoprotein, Platelets, Albumine, Impaired glucose tolerance,Aaspartat aminotransferase, platelets, albumin are measured by an accredited laboratory. The patients’ body mass indexes before and after taking the drug are calculated. If the evaluation confirms positive results, the extract of Cichorium intybus root can be used for the treatment of patients with non-alcoholic fatty liver disease. e aminotransferase level and compares it with the placebo in patients with non-alcoholic fatty liver disease. This study is a randomized double-blind clinical trial. A number of 60 people were selected for the study. Inclusion Criteria: age from 18 to 70 years; fatty liver disease grade 1, 2 or 3 diagnosed by ultrasound; No current use of another drug for fatty liver treatment which has not been taken before.Exclusion Criteria: Advanced Heart - cardiovascular, pulmonary or renal disease; Pregnancy; Breast feeding; Allergy to Cichorium intybus; Non-compliance with medication; Psychiatric diseases complicating the results evaluation or causing patient’s lack of cooperation; Advanced cirrhosis , Hepatitis and other liver diseases except non-alcoholic fatty liver;Aalcohol consumption by patients; Fatty acid oxidation disorder ( congenital );Patients with diabetes who are treated with insulin.
The duration of intervention is two months, where in the Intervention 1 Cichorium intybus root extract, and in the Intervention 2 corn starch.
Duration of intervention: 2 months
case 1: chicory root case 2: corn starch
Before and after taking the drug, Alanine aminotransferase ,Fasting blood suger, Total cholestrol,Triglycerides,High-density lipoprotein,Low-density lipoprotein, Platelets,Albumine, Imaired glucose tolerance,Aaspartat aminotransferase, platelets, albuminare are measured by an accredited laboratory.
The patients’ body mass indexes before and after taking the drug are calculated. If the evaluation confirms positive results, the extract of Cichorium intybus root can be used for the treatment of patients with non-alcoholic fatty liver disease.