The aim of this study is to assess the effect of acupressure on status of anxiety and respiratory in mechanically ventilated intensive care unit patients admitted in selected hospitals of Medical Science University in Tehran city. Inclusion criteria include GCS ≥ 9; patient intubated from past 24 hours; are on ventilation with SIMV ،PSV ،CPAP or BIPAP mode; have no neuromuscular illness and active heart disease; are not taking any neuromuscular blocker agent and are not taking sedative during past 4 hours. Exclusion criteria is weaning from ventilator during the study. In this randomized clinical trial, 90 patients are randomly placed in two groups, experimental and control, and patients will be blinded .Deep pressure in the experimental group and touch in the control group will perform at the 5- acupoints on both sides of the body .The intervention is performed two times per day over the two days and Each session of intervention will be lasted 20 minutes .Also it is performed at certain times of day for each patient by a trained person. The 5- acupoints include Zhongfu (Lu1), Taiyuan (Lu9), Hegu (Li4), Neiguan (Pc6) and Zusanli (St36). This technique is performed on one side of the body first and then the other side of the body, based on the patient's condition. Anxiety is measured by Faces anxiety scale and also the effects of anxiety on vital signs (blood pressure, mean blood pressure, heart rate, and respiratory rate and Oxygen saturation of arterial blood). Anxiety and vital signs will be measured baseline, before, immediately after and 2 hours after the intervention in the morning and evening for two days and then one day after the last intervention . The respiratory parameters (respiratory rate, tidal volume, peak inspiratory pressure, minute ventilation, dynamic compliance lung, airway resistance and rapid shallow breathing index) will be measured as a baseline, before, immediately after intervention, 15 minutes, every 30 minutes to 2 hours after the intervention in the morning and evening for two days and then one day after the last intervention. Blood gases at baseline and 2 times per day during the intervention and follow-up will be determined.