Comparison of Acid-Base and Electrolytes Imbalance in Normal Saline and Bicarbonate 1⁄6 Molar Intravenous Fluid Infusions during Cervical and Lumbar Laminectomy: A Pilot Double-Blinded Clinical Trial

This study aimed to compare electrolytes and acid-base imbalance occurrence in two fluid therapy methods using normal saline and 1/6 molar sodium bicarbonate in cervical and lumbar laminectomy surgeries. 35 to 70 years old patients with ASA class I and II, candidate for cervical and lumbar spinal laminectomy referred to Baqiyatallah Hospital in 2014 were enrolled. Patients with chronic kidney disease, hepatic failure, electrolytes imbalance, changes in blood pressure more than 30% of basal amount, needing blood transfusion before and during operation were excluded from study. Patients were randomized into two groups by a computer generalized list (20 patients in each group). Fluids needed were calculated in all patients. Maintenance fluid therapy was done using normal saline and deficit fluid therapy was done using 1⁄6 molar sodium bicarbonate in first group, while maintenance and deficit fluid therapies were done using normal saline in the second group. All other anesthesia processes were the same in the both group. Sodium bicarbonate 1⁄6 molar was produced using 150 mL sodium bicarbonate 7.5% added to 850 mL infusible distilled water identical in shape and size with normal saline fluid by another anesthesiologist. Drug prescriber, who filled the checklists in all stages as well as the person who performed the analysis were unaware of infused fluid in both groups. All patients were evaluated using arterial blood gasses, blood electrolytes levels, and hemodynamic factors before and after the operation. Collected data were compared between the two groups.

Baqiyatallah University of Medical Sciences, Deputy of Research