Eighty seven patients undergoing elective spine surgery with device are studied. The study examined patients in three groups of each 30 in A, B, C groups in a double-blind Randomized Clinical Trial. Exclusion criteria: acute or chronic renal failure; liver failure; nerve paralysis (Hemiplegia); spinal nerve injury; COPD (chronic obstructive pulmonary disease) and patient dissatisfaction. Moreover, patients addicted to drugs, alcohol or other drugs do not include in the study.
All patients or their guardians consent to be in the study and there is no obligations. Essential training about the standard visual analogue scale (VAS) is taught to patients in which the VAS shows to the patient marked 0-10 and 0 means No Pain and number 10 shows the Worst pain unbearable. Furthermore, to all patients Pulse oximeter, Non Invasive and Invasive blood pressure, end-tidal CO2 and temperature monitoring are given in the operation room. BIS monitoring is performed for all patients. After preoxygenation with facial mask and premedication with Midazolam 0.03 mg/kg and 1-3 microgram /kg Fentanyl patients will anesthetized by Propofol 2 Mg/Kg and Atracurium 0.5 mg/kg; moreover, after 3 minutes patient will intubate with tracheal tube. Anethesiologist and surgery team is the same for all patients. For maitenance propofol 100-150 microgram\kg\hr and Atracurium 0.2 mg per every 30 minutes is used. The analgesia for Group A Fetanyl and for group B and C Remifentanil is used. Moreover, at the end of 20 minutes of surgery, Apotel 15 mg\kg is used for group A and B but in group C is morphine 0.05 mg\kg. 30 minutes after patients stay at recovery room, 6, 12, 24, 48 after surgery vital signs, Visual Analouge Scale, Ramsey Sedation Score and the absence of existence of Post Operation Vomiting and nausea and Respiratory depression due to the prescribing morphine will be measured.