Comparative study on potential of platelet-rich plasma Gel and regular dressing in duration of wound healing in patients who underwent pilonidal sinus surgery

The aim of this study was to investigate the influence of platelet- rich plasma (PRP) Gel therapy on wound healing in patients with pilonidal sinus after surgery. One hundred twenty three patients who had surgery for pilonidal sinus were enrolled in this single center phase III clinical trial. All patients were treated by wide excision and open secondary intention. Exclusion criteria were as follows: lower platelet count of <1000/µL, hemoglobin <10 mg/dl, anti-proliferative therapies such as chemotherapy and also radiation in past 3 months, anti-inflammation medications in past 2 weeks, growth factor therapies in last 2 weeks, history of diabetes, history of mal-absorption (celiac disease) and any contra-indication in peripheral venues access. After assessment of eligibility criteria, patients were randomized into control and PRP treatment groups using block method. In PRP group, the obtained PRP was additionally injected into the depth (13mm) of the wound. It was also applied to center of each circle (0.1cc) and wound site (1 cm in diameter) through injection. PRP Gel was then added to the 2ml/cm3 of wound volume and the casual dressing was performed. Classical dressing (sterile absorbent cotton gauze) was applied for the control group. In both groups, the wounds were washed by normal saline (0.9%) twice a day. Wound debridement was also performed to remove the necrotic tissues if necessary. Quality of life and healing duration were evaluated in both groups up to the end of the study.

Vice chancellor for research, Tehran University of Medical Sciences