In this double blind clinical trial, 40 patients poisoned with carbon monoxide eligible to enter the study after informed consent were randomly divided into two groups drug and placebo. After diagnosis of carbon monoxide poisoning during the 12 hours of the onset, colony stimulating factor granulocyte (G-CSF) or placebo at a dose of 180 μg / Kg was given as a continuous infusion over 72 hours. In the times before and after 0.5, 1, 2, 5, 8, 12, 24, 48 hours after administration of G-CSF, blood samples from patients were taken and G-CSF concentration using ELISA was evaluated. For patients Holter monitoring ECG closed and within 24 hours of poisoning all arrhythmia's, especially ventricular arrhythmia's were recorded. Changes in T and ST segment related to ischemia were recorded. patient's vital signs every 4 hours during the first 24 hours, every 6 hours during the second and third days were recorded. Score (NIHSS) in Day 1 (pre-intervention), 3 and 30 after intervention and Modified Rankin and Barthel score at day 30 were measured and recorded. Index STR percentage, serum (TPI) in 3, 12, 24, 48 and 72 hours after intervention were recorded. The concentration of serum GFAP, Myeloperoxidase, S100β, IL6, MBp using ELISA , serum carboxyhemoglobin with GC-mas and (Brain MRI) before the intervention and at 1, 3 and 30 after intervention were measured.