Goal: Assessment effect of vitamin D supplementation on insulin resistance in women with poly cystic ovarian syndrome
Drawings: The diagnosis of PCOS was based on the Rotterdam criteria, which necessitated 2 of the following 3 features:1. oligoovulation and anovulation (less than 6 times in 12 months ) 2. clinical or biochemical signs of hyperandrogenism such as acnea, allopecia or high androgen level 3. polycystic ovaries on ultrasound examination and the patients have vitamin D deficiency were included.
Design: The questionnaires were included height, weight, body mass index, waist, menstruation pattern, infertility.Tests, fasting glucose, fasting insulin, insulin resistance index were measured in these patients.Inclusion criteria: Women who were between 20 and 40 years old, were vitamin D deficient, and had PCOS diagnosed by a gynecologist
Exclusion criteria: Patients who were diagnosed with Cushing syndrome, congenital adrenal hyperplasia, hyperprolactinemia, hypothyroidism, hyperthyroidism, andogen secreting tumor, all systemic disease affect vitamin D level such as liver disease, renal dysfunction, malabsorption syndrome, alcholism, lactation, pregnancy, medications known to affect metabolic parameters, such as metformin and corticosteroid drugs,vitamin D, and serum calcium
Intervention: The patients received a single dose of vitamin D and the piolt checked again two months after treatment.Written consent form was obtained from all patients.
Primary outcome measure:
Fasting glucose
Fasting insulin
HOMA IR
Secondary outcome measure: Height, Weight, 25 hydroxy vitamin D, Body Mass Index