Comparison of ovulation induction by GnRH antagonist (Cetrotide) in patients with poor ovarian response with the previous ART(Assisted Reproductive Technology) cycles

The main objective of this study is determining the outcome of antagonist ovulation GnRH (Cetrotide) in infertile women with poor ovarian response in the previous ART (Assisted Reproductive Technology). Inclusion criteria: history of poor response to stimulation (<3 dominant follicles or estradiol <500pg/ml), basal FSH level>10 mIU/ml, antral follicle count <5. Exclusion criteria: endometriosis, only one ovary, endocrine or metabolic disorder. Forty poor responders in previous ART which performed three months earlier are selected and the data of their previous cycle such as the number of follicle and oocyte, the number and the quality of embryo …, retrieve from documents. Medical orders are given as follow: Fustimone 300 unites daily after third day and vaginal sonography after ninth day of cycle are initiated. If in first sonography, follicles with 14mm diameter or more cannot identified, sonography is performed every two days until 14mm follicle can be seen and then Cetrotide (0.1mg/day) will be injected and Fustimone and daily sonography will be sustained. When one or two 16 to 18mm follicles are detected in sonography, 1000 unit of HCG is injected and the two previous drugs will be discontinued. Thirty six hours after HCG injection, puncture of ovary is performed and oocytes are sent to laboratory and the quality and quantity of them will be documented. The grading of embryo is determined numerically and recorded. The data related to follicles’ number in sonography and retrieved oocytes will be compared with the records of previous cycle.

Vice chancellor for research, Kerman University of Medical Sciences