Objectives: The aim of this study is to compare sonographic right internal jugular vein catheterization with short axis method in nautra Ihead position via medial-oblique technique in 45 degree head position in open heart surgery. Research Design: Conduction of a randomized, double-blind, clinical trial. Inclusion criteria of the study were as follows: Open-heart surgery patients, age above 18 years, Patients’ consent to participate. Exclusion criteria of the study were: cannulation site infection/wound/hematoma/emphysema and surgery, intensive coagulopathy, IJV cannulation during the past 72 hours, recent cervical trauma with movement limitations, anatomical changes in the cervical vessels, IJV thrombosis with the short axis technique in open-heart surgery patients. Intervention: After induction of anesthesia 80 patients were divided into two groups of 40, Short Axis Group and Medial-Oblique Group. For short-axis technique, the patient’s head was positioned at 0-degree angulation with his trunk. For medial-oblique technique, the patient’s head was tilted to left to 45 degrees between the head and trunk. Venous access time, guide wire time, cannulation time, total attempts for catheterization, total successful first attempts, number of arterial puncture, bleeding and hematoma at the puncture site and proper catheter placement were recorded and success rate of each technique, duration of different catheterization steps, primary mechanical complications for comparison of these techniques were determined in the operating room and also 7 hours after CABG in the ICU by chest X-ray .