Comparison of intravenous Dexmedetomidine and Clonidine in change of hemodynamic parameter and block quality after spinal anesthesia with Ropivacaine in lower limb orthopedic surgery
Aim of this study is to compare of intravenous Dexmedetomidine and Clonidine in change of hemodynamic parameter and block quality after spinal anesthesia with Ropivacaine in lower limb orthopedic surgery. This study clinical trials and double blind. We will enter 120 patients with spinal anesthesia in lower limb orthopedic surgery in Valiasr hospital. We will inject 0.1 Dexmedetomidine micro gram in kilogram in hours in first group and 0.2 Clonidine micro gram in kilogram in hours in second group and 50 milliliter in litter normal salin. We will record blood pressure and heart rate and oxygen saturation percent in duration surgery every 15 minute. We will sensory block every 1 minute with pin prick method and motor block every 5 minute with Bromeg scale. We will record visual analog scale in recovery and 1 and 2 and 4 and 6 and 12 hours after surgery. Patient refusal to perform spinal anesthesia; failure to perform spinal anesthesia; body mass index more than 30; history of the use of beta-blockers and alpha-2 agonists and calcium channel blockers; cardiovascular disease; pregnancy; coagulation disorders; localized infection in the spinal cord ;history of allergy to the drugs of dexmeditoimidine and clonidine and rupivacaine; arrhythmia; psychological problems; peripheral and central neuropathy
General information
Acronym
IRCT registration information
IRCT registration number:IRCT2017092020258N60
Registration date:2017-10-28, 1396/08/06
Registration timing:registered_while_recruiting
Last update:
Update count:0
Registration date
2017-10-28, 1396/08/06
Registrant information
Name
Fariba Farokhi
Name of organization / entity
Arak University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 86 3222 2003
Email address
f.farokhi@arakmu.ac.ir
Recruitment status
Recruitment complete
Funding source
Vice Chancellor for Research of Arak University of Medical Sciences
Expected recruitment start date
2017-04-04, 1396/01/15
Expected recruitment end date
2020-03-12, 1398/12/22
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Comparison of intravenous Dexmedetomidine and Clonidine in change of hemodynamic parameter and block quality after spinal anesthesia with Ropivacaine in lower limb orthopedic surgery
Public title
Comparison of intravenous Dexmedetomidine and Clonidine in change of hemodynamic parameter and block quality after spinal anesthesia with Ropivacaine in lower limb orthopedic surgery
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria: 18 to 60 years; ASA class I and II; both male and female; patients with lower limb orthopedic surgery
Exclusion criteria: Patient refusal to perform spinal anesthesia; failure to perform spinal anesthesia; body mass index more than 30; history of the use of beta-blockers and alpha-2 agonists and calcium channel blockers; cardiovascular disease; pregnancy ; coagulation disorders; localized infection in the spinal cord ;history of allergy to the drugs of dexmeditoimidine and clonidine and rupivacaine; arrhythmia; psychological problems; peripheral and central homeopathy
Age
From 18 years old to 60 years old
Gender
Both
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
120
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Ethics committee Arak University Of Medical Sciences