Title: A histologic, histomorphometric and radiographic comparison between two complex of Cenobone/ Cenomembrane and Bio Oss/ Bio Gide in lateral ridge augmentation: a preliminary study.
Objectives: The aim of this study is to compare Cenobone/ Cenomembrane and Bio Oss/ Bio Gide in lateral alveolar bone augmentation.
Design: This single blind randomized clinical trial is conducted on eight sites which require lateral bone augmentation.
Setting and conduct: Samples are selected from subjects seeking implant replacement within the age range of 30 to 50 years and require bone augmentation who present department of periodontology and implant, Faculty of dentistry, Babol University of Medical sciences. The minimum required sample size is evaluated to be 8 for conducting semi experimental clinical trial.
Major Inclusion and Exclusion criteria: Samples with alveolar bone width of 2 to 4 mm at distance of 3 mm from the crest are included in the study. Patients with certain systemic conditions which affect healing process, patients with poor compliance, sufferers from active periodontal diseases and subjects who don't want to participate in the study are excluded.
Intervention: Patients matching is performed with regard to gender, age, general health, and smoking state of subjects. Patients are assigned to either of two experimental groups. Surgical process is conducted using either of Cenobone/ Cenomembrane and Bio Oss/ Bio Gide in each group.
Main outcome measures: six months later at reentry surgery, core biopsies are taken and trabecular thickness, percentage of osseous formation, extent of inflammation, foreign body reaction, vitality, biomaterial/bone contact, and number of blood vessels are evaluated by means of histologic and histomorphometric observations. The radiographic width of alveolar ridge at initial and reentry surgeries is measured using CBCT.