The most persistent rhythm in treatment of cardiac arrest is asystole rhythm. In this situation, the survival is low. Although epinephrine is the choice but some studies suggested vasopressin as an alternative drug .This study’s purpose is to compare effects of vasopressin and epinephrine in the patients with asystole rhythm.Inclusion criteria is including the patients with Asystole rhythm.
Exclusion criteria are including : Ventricular Fibrilation ؛ Pulssless Ventricular Tachycardia ؛ Pulseless Electrical Activity ؛ Do Not Resuscitation protocol ؛ Pregnancy ؛ Hemorrhagic shock ؛ CPR after 20 minutes. This double blind clinical trial will perform on 210 patients with asystole rhythm. 105 patients will receive epinephrine (group 1) and 105 patients vasopressin (group 2) as first drug. Next, American Heart Association guideline 2010 willperform in both of them. Then data collection such as age, sex, Return Of Spontaneous Circulation (ROSC), the survival of 1 hour, 24 hours and one month, heart rate after resuscitation and survival to discharge.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT2015050922181N1
Registration date:2015-06-30, 1394/04/09
Registration timing:retrospective
Last update:
Update count:0
Registration date
2015-06-30, 1394/04/09
Registrant information
Name
Mehdi Torabi
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 913 199 2016
Email address
mtorabi1390@yahoo.com
Recruitment status
Recruitment complete
Funding source
Kerman University Medical Sciences
Expected recruitment start date
2011-03-20, 1389/12/29
Expected recruitment end date
2013-03-20, 1391/12/30
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effect of vasopressin and epinephrine in cardiac arrest outcomes in patients with asystole rhythm
Public title
Vasopressin effect in asystole rhythm patients
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria: Patients with Asystole rhythm
Exclusion criteria: Ventricular Fibrilation; Pulssless Ventricular Tachycardia; Pulseless Electrical Activity; no resuscitation; Pregnancy; Hemorrhagic shock; CPR after 20 minutes
Age
No age limit
Gender
Both
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
210
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Kerman Univercity Medical Sciences
Street address
After shafa cross-street, jomhoori street, kerman
City
Kerman
Postal code
7618747653
Approval date
2015-05-23, 1394/03/02
Ethics committee reference number
IR.KMU.REC.1394.117
Health conditions studied
1
Description of health condition studied
Cardiac arrest
ICD-10 code
146.0
ICD-10 code description
Cardiac arrest with successful resuscitation
Primary outcomes
1
Description
Return of Spontaneous Circulation
Timepoint
After cardiac rhythm change
Method of measurement
Carotid pulse check
2
Description
Heart rate per minute
Timepoint
After return of circulation
Method of measurement
Cardiac monitoring
3
Description
Patient survival time
Timepoint
First hour, First day, First month
Method of measurement
Patient survival (having respiration and cardiac rhythm)
4
Description
Total patient survival time
Timepoint
After return of circulation
Method of measurement
Minute
Secondary outcomes
empty
Intervention groups
1
Description
Intervention group: Vasopressin 40 unit intravenous will be pushed in asystole group patients. If there is no response, epinephrine will be pushed every 5 minutes.
Category
Treatment - Drugs
2
Description
Control group: Epinephrine 1 mg intravenous will be pushed in asystole group patients. If there is no response, epinephrine will be pushed every 5 minutes.
Category
Treatment - Drugs
Recruitment centers
1
Recruitment center
Name of recruitment center
Afzalipoor Hospital
Full name of responsible person
Mehdi Torabi
Street address
Kerman , Emam khomeini Avenue
City
Kerman
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Kerman University Medical Sciences
Full name of responsible person
Assistance of Research and Technology
Street address
After shafa cross-street, jomhoori street, kerman
City
Kerman
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Kerman University Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Kerman University Medical Sciences
Full name of responsible person
Mehdi Torabi
Position
Assistant Professor
Other areas of specialty/work
Street address
After shafa cross-street, jomhoori street, kerman
City
Kerman
Postal code
7618747653
Phone
+98 34133151912
Fax
+98 34 3211 4278
Email
mtorabi1390@yahoo.com
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Kerman University Medical Sciences
Full name of responsible person
Mehdi Torabi
Position
Emergency Medicine Specialist
Other areas of specialty/work
Street address
After shafa cross-street, jomhoori street, kerman
City
Kerman
Postal code
7618747653
Phone
+98 34 3315 1912
Fax
+98 34 3211 4237
Email
mtorabi1390@yahoo.com
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Kerman University Medical Sciences
Full name of responsible person
Mehdi Torabi
Position
Assistant Proffesor
Other areas of specialty/work
Street address
After shafa cross-street, jomhoori street, kerman
City
Kerman
Postal code
7618747653
Phone
+98 34 3315 1912
Fax
+98 34 3211 4278
Email
mtorabi1390@yahoo.com
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)