Comparing the effects of Propofol and Propofol-Ketamine anesthesia maintenance regime on hemodynamic parameters during anesthesia and postoperative complications in patients undergoing leg fracture surgery

(1)Objectives: Comparison of the effects of two anesthesia maintenance regime on hemodynamic parameters during anesthesia and postoperative complications in patients with leg fracture.(2)Design: The study was performed as randomized double-blind clinical trial on 94-95 on 60 patients who candidate for surgery and trial phase was 3. (3)setting and conduct:Patients were randomly divided to Propofol or Propofol – Ketamine group.All patients were anesthetized with 2mg/kg Propofol, 5μg/kg Fentanyl, and 0.5 mg/kg Atracurium after which one group of patients received Propofol (100 μg/kg/min) and the other group received a combination of Propofol Ketamine(50µg/kg/min Propofol and 25µg/kg/min Ketamine).(4)participants including major eligibility criteria:Patients who were candidate for leg fracture surgery with class 1 and 2 ASA and aged 15 to 45 years old entered the study.Patients who had addiction and had a history of motion disease were excluded.(5)interventtion: use of 2mg/kg Propofol, 5μg/kg Fentanyl, and 0.5 mg/kg Atracurium in both group for induction and use of Propofol 100 μg/kg/min in one group and of Propofol Ketamine combination (50µg/kg/min Propofol and 25µg/kg/min Ketamine) in another group for maintenance regime . (6)main outcome measures: Heart rate, systolic and diastolic blood pressure, and MAP recorded when the patient is lying on the bed before induction, one minute after induction,after laryngoscopy and intubation and then in 10-minute intervals to the end of the procedure.Pain, nausea and vomiting after the patients were conscious up to 6 hours after the patient is sent out of recovery in 2-hour intervals using VAS criterion measured and analysised.

Vice chancellor for research and technology affairs of Birjand University of Medical Sciences (BUMS)