Protocol summary

Summary
Objectives: Infants born prematurely are vulnerable. Many premature infants because of in coordination between sucking, swallowing and breathing, may need alternative feeding methods, until the development of skills which necessary for oral feeding. Design: 3 groups, single blind randomized control trial. Setting and conduct: Neonatal intensive care unit (NICU) of one university hospital in Shiraz city. Participants: 90 healthy preterm newborns, Fetal age between 30-34 weeks; Birth weight appropriate for gestational age(AGA); Apgar score at 1 and 5 min after birth ≥ 7; Non addicted mothers; No need for phototrapy; No need for complete parental feeding, will randomly assigned to three groups: two experimental groups and control group and will Excluded if Un willingness the parents for complete the study; Need for transfer to other wards or other hospitals; Received drugs that affect central nerves system; Need for surgical and medical interventions during study; Need for photo therapy during study; Received other supportive intervention; Abnormal physiologic response during intervention; Missing of intervention at least twice during study. Intervention: Non-nutritive sucking with finger and pacifier that will be carried out by mothers in 10 first minuets of gavages' feeding, three times a day. Main outcome: Neonate’s weight will be evaluated daily by trained midwife until discharge day, also the initiation of breast feeding and the time of discharge will be recorded.

General information

Acronym
IRCT registration information
IRCT registration number: IRCT201106062324N8
Registration date: 2012-03-17, 1390/12/27
Registration timing: registered_while_recruiting

Last update:
Update count: 0
Registration date
2012-03-17, 1390/12/27
Registrant information
Name
Maryam Keshavarz
Name of organization / entity
Iran University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 21 4365 1813
Email address
keshavarz@iums.ac.ir
Recruitment status
Recruitment complete
Funding source
vice chancellor for research- Tehran University of Medical Sciences
Expected recruitment start date
2011-10-23, 1390/08/01
Expected recruitment end date
2012-03-20, 1391/01/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Non-nutritive sucking with pacifier and finger on weight gaining, initiation of breastfeeding and discharge of preterm newborns, in neonatal intensive care unit, Hazrat Zynab hospital, Shiraz
Public title
The impact of non-nutritive sucking with pacifier and finger on weight gaining, initiation of breastfeeding and discharge of preterm newborns.
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria: Fetal age between 30-34 weeks; Birth weight appropriate for gestational age(AGA)); Apgar score at 1 and 5 min after birth, ≤ 7; Normal neonate (no evidence of congenital anomaly such as respiratory and heart problems, seizure, CNS hemorrhage …); Non addicted mothers; No need for phototherapy; No need for complete parental feeding. Exclusion criteria: Un willingness the parents for complete the study; Need for transfer to other wards or other hospitals; Received drugs that affect central nerves system for example: Phenobarbital and phenytoin; Need for surgical and medical interventions during study; Need for photo therapy during study; Received other supportive intervention such as touch therapy, kangaroo care, music therapy and other intervention during study; Abnormal physiologic response such as heart rate above 200 beat per min or under 100 beat per min, deceleration of oxygen saturation level under 80% during intervention; Missing of intervention at least for two times during study.
Age
To 1 year old
Gender
Both
Phase
2
Groups that have been masked
No information
Sample size
Target sample size: 90
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Single blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

1

Registry name
No
Secondary trial Id
No
Registration date
empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethical commitment of Tehran University of Medical Sciences
Street address
Sixth floor ,Central office, Ghods St, Keshavarz Blvd- Tehran, Iran
City
Tehran
Postal code
Approval date
2011-08-11, 1390/05/20
Ethics committee reference number
786

Health conditions studied

1

Description of health condition studied
weight gaining- time of discharge- Initiation of breast feeding
ICD-10 code
P07.3
ICD-10 code description
سن حاملگی کمتر از 28 هفته یا 196 روز کامل

Primary outcomes

1

Description
Weight
Timepoint
Daily
Method of measurement
neonat weight will be taken without cloth on an electronic weighing scale with an accuracy of ± 10 grams.

Secondary outcomes

1

Description
The initiation of breastfeeding
Timepoint
The first time that neonate will be able to sucking and breastfeeding
Method of measurement
Observation and record in checklist

2

Description
The time of discharge
Timepoint
at the time of discharge
Method of measurement
Observation and record in checklist

Intervention groups

1

Description
Non- nutritive sucking with pacifier and finger
Category
Prevention

2

Description
No intervention will be done in control group
Category
Prevention

Recruitment centers

1

Recruitment center
Name of recruitment center
Hazrat Zynab treatment and educational centre
Full name of responsible person
Zahra Rajaee
Street address
Shiraz
City
Shiraz

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Vice chancellor for research- Tehran University of Medical Sciences
Full name of responsible person
Dr. Akbar Fotohi
Street address
Sixth floor ,Central office, Ghods St, Keshavarz Blvd- Tehran, Iran
City
Tehran
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice chancellor for research- Tehran University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty

Person responsible for general inquiries

Contact
Name of organization / entity
School of Nursing Midwifery, Tehran University of Medical Sciences
Full name of responsible person
Maryam Keshavarz
Position
Assistant Professor in Midwifery Education
Other areas of specialty/work
Street address
Midwifery dep, School of Nursing Midwifery, Tehran University of Medical Sciences, West Nosrat St, Tohid Sq, Tehran.Iran
City
Tehran
Postal code
Phone
+98 21 6105 4219
Fax
Email
Keshavarz_m@tums.ac.ir ; m_keshir@yahoo.com
Web page address

Person responsible for scientific inquiries

Contact
Name of organization / entity
School of Nursing Midwifery, Tehran University of Medical Sciences
Full name of responsible person
Maryam Keshavarz
Position
Assistant Professor in Midwifery education
Other areas of specialty/work
Street address
Midwifery dep, School of Nursing Midwifery, Tehran University of Medical Sciences, West Nosrat St, Tohid Sq, Tehran.Iran
City
Tehran
Postal code
Phone
+98 21 6105 4219
Fax
Email
Keshavarz_m@tums.ac.ir ; m_keshir@yahoo.com
Web page address

Person responsible for updating data

Contact
Name of organization / entity
School of Nursing Midwifery, Tehran University of Medical Sciences
Full name of responsible person
Maryam Keshavarz
Position
Assistant Professor in Midwifery education
Other areas of specialty/work
Street address
Midwifery dep, School of Nursing Midwifery, Tehran University of Medical Sciences, West Nosrat St, Tohid Sq, Tehran.Iran
City
Tehran
Postal code
Phone
00
Fax
+98 21 6690 4252
Email
Keshavarz_m@tums.ac.ir ; m_keshir@yahoo.com
Web page address

Sharing plan

Deidentified Individual Participant Data Set (IPD)
empty
Study Protocol
empty
Statistical Analysis Plan
empty
Informed Consent Form
empty
Clinical Study Report
empty
Analytic Code
empty
Data Dictionary
empty
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