In this study for the first time we evaluate the effects of dietary energy reduction and increase fiber intake to individuals with polymorphisms T-C 256- APOAII. This study is a non-randomized, not blinded and without placebo that is done on 56 patients with type II diabetes. Diabetic samples will elect from 800 samples which has been collected in the previous study and took in two groups of CC genotype and T allele carrier group includes TT or TC. Of these, 28 patients with CC genotype are selected. Inclusion criteria are an age range between 45 to 65 years, BMI greater than or equal to 27 and any injection of insulin. Exclusion criteria consist of use of tobacco and alcohol, patients with chronic inflammatory diseases and use of Anti-inflammatory medications or multivitamin and mineral supplements. The t allele carrier group will be homologized in terms of gender, receiving lipid-lowering drugs, BMI and age with CC group. Patients will receive low-energy diet( 500-1000 calorie less than their needs), rich in fiber (30 grams per day) during 6 weeks. Blood samples will be taken before the study and at the end of the intervention and the levels of certain serum factors such as TNF-α, NFKB, ICAM1, VCAM1 and HDL2 and HDL3 and enzyme LCAT, PON1, PON3 and their relationship with APOA-I and APOA-II we will study. The gene expression of PTX3, VCAM1, ICAM1 will be measured.