Comparative study of bolus and intermittent tube feeding impacts on intolerance nutrition and respiratory aspiration among sepsis patients in intensive care unit

Objectives: This study is a clinical trial aiming to compare the tube feeding and bolus alternative methods on the level of nutrition intolerance and aspiration among hospitalized intensive care unit patients with sepsis. Design: Random allocation Setting and conduct: Sixty patients with diognosis of sepsis that were admitted to the intensive care unit of the Shahid Chamran hospital. Major Inclusion criteria: Patients aged between 18 to 65 years old ؛ hospitalized in intensive care units ward ؛ and with confirmed diagnosis of sepsis ؛ level of consciousness lower 10 and with intubated. Major Exclusion criteria : Any patient with increased or enough alertness and natural ability to eat while the study is conducted؛ discharged from the ICU before 10th day of hospitalization؛ hemodynamic disorders؛ need for new therapeutic interventions؛ history of dehydration symptoms؛ addiction.s Interventions: First stage: Pre-test level in which patients to be assessed for study inclusion criteria. Second stage: patients randomly divided into three groups based on random allocation including: bolus, intermittent and continuous nutrition. Third stage: intervention study For these three noted methods for feeding, a Check list of steps will be prepared dependent upon related variables. Fourth stage: Three days after the beginning of the study, patients will classified into three groups according to the criteria of the nutrition intolerance and respiratory aspiration. main outcome measures: constipation؛ vomiting؛ residual volume؛ distension of gastric؛ Diarrhea

Vice chancellor for research, Aja University of Medical Sciences