Evaluation of inhalation and IV form of lidocaine on hemodynamic responses in patients undergoing Endotracheal intubation

Single-blind randomized clinical trial study will done to evaluate the effect of inhaled and intravenous lidocaine on hemodynamic response in endotracheal intubation patient that hospitalized in ICU and between 25 to 40 years old in Arak Vali-Asr Hospital. Patients randomized to 3 groups (1, 2 intervention and control). The sample size was estimated for each group of 64 patient. In 1st intervention group 0.75 mg/kg lidocaine 4% will sprayed to the larynx and gloat, 2 minutes before intubation and the same dose will sprayed at intubation time. In 2th intervention group 0.75 mg/kg lidocaine 2% was injected intravenously, 2 minutes before intubation and the same dose will injected at intubation time. The main drugs used in the control group and of any type of lidocaine is not used. Inclusion criteria: patients between 25 to 40 years old admitted to the ICU and indication for endotracheal intubation; patients without underlying disease such as diabetes, hypertension, cardiovascular disease, kidney and liver diseases, respiratory diseases, recent respiratory infection; patients classified for 1 or 2 ASA; obtaining informed consent from attendant patients for the study. Exclusion criteria: patients who had a history of lidocaine hypersensitivity; pregnancy and lactation The systolic and diastolic blood pressure, mean arterial pressure and heart rate in the intervention groups 1 and 2 and the control group will determined.

Deputy Minister for Research and Technology َArak University of Medical Sciences