Objective: Survey efficacy of the fibrinogen and Fresh frozen plasma in the hemodynamic and clinical outcomes of patients with severe trauma. Design: In this interventional study, a total of 40 consenting patients will be selected and divided in two groups using block randomization method (n=20 in each group). Proper counseling will be done and a written informed consent will be obtained before starting the treatment regimen. Inclusion criteria: Age over 18 years old; patients with multiple trauma; need for repeated transfusion; injury severity score 16 and above; satisfaction to participate in the study. Exclusion criteria: Unwillingness of the patient to continue cooperation in the plan; trauma limited to head; Penetrating trauma; injury severity score less than 16. Setting and conduct: The first and second groups will be treated with fibrinogen extract (70 mg/kg, every 8 hours until the INR reaches under 1.8 ) and FFP 10 – 15 mg/kg, every 8 hours until the INR reaches under 1.8 ) made by Iranian Blood Transfusion Organization respectively. Blood pressure, pH level, oxygenation index 4 and 12 hours after the beginning of the intervention and Patients' demographic information, types of brain and organ damage, level of consciousness, days requiring mechanical ventilation, number of blood units taken, the occurrence of multi organ failure, the duration of hospitalization and death of the patients will be recorded in the questionnaire. Data collected will be compared between the two groups by statistical tests. Outcomes measure: Blood pressure, pH level, oxygenation index; types of brain and organ damage; level of consciousness; days requiring mechanical ventilation, number of blood units taken, the occurrence of multi organ failure, duration of hospitalization and death of the patient.