Effect of vitamin D3 on glycemic control, inflammatory markers and 24hr urine protein in patients with insufficiency and deficiency in serum vitamin D level in type 2 diabetes mellitus

The purpose of this study is to evaluate the ‏Effect of vitamin D3 on glycemic control & inflammatory markers & 24hr urine protein in patients with insufficiency and deficiency in serum vitamin D level in type 2 diabetes mellitus. Inclusion criteria include: patients with type 2 diabetes treated with insulin or medication to lower blood sugar levels; have a vitamin D deficiency; insulin and blood sugar-lowering drugs are used on a regular basis; during the last month are not taking calcium and vitamin D supplementation; proteinuria more than 200 mg per 24 hours urine; the serum creatinine less than 2 or GFR above 50. Exclusion criteria: type 1 diabetes; the normal level of vitamin D; not cooperating with the regular use of drugs; serum creatinine greater than 2 or GFR less than 50; D Calcium intake during the last month; unwillingness to continue to participate in the study; calcium in phosphorus above 55; calcium greater than 10, all conditions that affect the ESR, except for the lack of vitamin D. Sixty diabetes type II patients examined by serum biomarker measurement (vitamin D level, fasting blood glucose, HbA1C, 24 –hour urine protein, ESR, CRP). The patients with vitamin D deficiency divided to case and control groups. Case group treated by pearl vitamin D 50000 units, and control group by placebo for a two month. In the end of study, the same biomarkers examined again and compared with before treatment measurements in both groups.

Shahrekord University of Medical Sciences